ID A0A3Q4GHB8_NEOBR Unreviewed; 2339 AA.
AC A0A3Q4GHB8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Unconventional myosin-XVIIIa-like {ECO:0000313|Ensembl:ENSNBRP00000008575.1};
GN Name=MYO18A {ECO:0000313|Ensembl:ENSNBRP00000008575.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000008575.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000008575.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 32507.ENSNBRP00000008575; -.
DR Ensembl; ENSNBRT00000008826.1; ENSNBRP00000008575.1; ENSNBRG00000006624.1.
DR GeneTree; ENSGT00940000155768; -.
DR OMA; RTRMDEP; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000006624; Expressed in muscle tissue and 8 other cell types or tissues.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01386; MYSc_Myo18; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 2.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR036064; MYSc_Myo18.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF13; UNCONVENTIONAL MYOSIN-XVIIIA; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR Pfam; PF00595; PDZ; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
FT DOMAIN 217..308
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 423..1036
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1296..1328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1707..1727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1876..1897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2013..2053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2093..2112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2161..2339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1100..1197
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1368..1530
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 121..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2013..2050
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2161..2184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2203..2221
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2222..2238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2239..2253
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2259..2291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2312..2339
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 516..523
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2339 AA; 265179 MW; CB511CAE90C56A31 CRC64;
MFNLKKKEKE KKEKKERMSA AELRSLEEMS MRRGFFNLKR ESKRESRNKL EISNPIPIKV
ASTSDLPLTD IELDGLSNRS SMILDDQLSI ASSNDDLKGE GGGGQDGQRS SVRDRVAHFG
SLAKQNSTQM MKRFSFSQRS KEESPSEGST PSGQNSAAPS PQVESKVFSM LRKHSLKQQP
GAEAPKRICI PEVVDKTFPA QLQLPAVVAP SPPETRELEL QRRNTGDFGF SLRRTTMLDR
SPDGGVYRRV VHFAEPGAGT KDLALGLVPG DRLVEINGRN VENKSRDEIV EMIRQSGDTV
RLKVQPILEL SELSRFWLRN TEGLRREARL GSVEEDLIAL QASHAAAKQS QVKTEEQIAA
EQAWYESDKV WLVHKDGFSL ATVIKTETGS LPEGKVRIKM EHDGTVLDVD EDDIEKANPP
SYDRSEDLAS LLYLNESSVM HCLRQRYGGN LIHTYAGPNM VVINPLSVPS MYSEKVMNMF
KGCRREDSAP HIYSVAQSAY RNLLTTRQDQ SIVLLGRSGS GKTTNCQHLV QYLVCIAGST
GKIFSAEKWQ AVYTILEAFG NSSTTTNTNA SHFSHVVSLD FDQAGQVASA SIQTMLLEKL
RVSRRPEGES TFNVFYYMMA GADSSLRTEL HFNHLAENSA FGILPQTKPE DKQRSLQHFT
KLQAAMKVLG ISSEEQKAIW LILGAIYHLG AAGATKVGRR QFARHEWAQK AAYLLGCTLE
ELSSSIFKHQ VRTLARTDEA RGLLWLMEEE AVHPGGSEET MLERLFSYYG SAQGENKGAN
LLLRGEKPHL FLLGHSHGTN WVEYNTQGWL NHAKHNPAAQ NAATLLQDSQ KKNISALFMG
RASGATVLSG SIAGLEGSSQ LALRRATSMR KTFTTGVAAV KKKSLCIQVK LQVDALIDMV
RRSKVHFVHC LLPKVEAVGG GDYRMAHGES PDSGLMTLDV SLLRAQLRGS KLLDALRIHR
QGYPDHMVFS EFRRRFDVLA PHLTKKYGRH YIVTDEKRAV EELLESLELE KSNYHMGLSR
VFFRAGILSR LEEQRDFQTR RNISLFQAAC RGYLARQAFK KRKIQDLAIR CIQKNIKKNR
GVKGWPWWKL FTTVRPLIEV QLTEEQIRGK DEEIQQLKQK LEKVEKERNE LRLNSDRLES
RITELSAELA DERNTGESAS QLLETETSER LRLEKDMKDL QAKFDSTKKE MESMEMEVME
ARLIRASELS GEVDDDETGG EWKLKYERAI REIEFTKKRL QQELDDKLEV EQQNKRQILF
VQISDLEADY EESQRNIQQL KKKAQRLTAE LQDTKLHLEG QQSRNHDLEK KQRKFDSELS
AAQDEVQRER SLREKLAREK DVLTGEVFGV RQQLEDKDLE ACAVNLKLEQ LEAELQDLNS
QESKDEASLA KVKKQLRDLE AKVKDQEEEL DEQAGTIQML EQGKLRLEME MERLRQTHSK
EIENKDEEVE EIRQSCSKKL KQMEVQLEEE YDEKQKVLKE KRELESNFLS VQDQVRGGDI
EVEKRLRKDL KRTKALLADA QIMLDHIKNN APSKREIAQL KNQLEESEFT CAAAVKAKKS
MEVEIEDLHV QMEDISKTKQ ALEEQLSRLQ REKNDLQSRM EEDQEDFNEL MKKHKAAVAQ
SAQNLAQISD LQAQLEDALK EKQEIQEKMQ ALQSQMEFQE QSMVEKSLVS RQEAKCRELE
TKLEFEKTQV KRLESHLARL KENLEKLTEE RDQRSSGEIR EKEQNKRFQR QIRDIKEETA
ELAKKEAEAS RKKHELEMDI ESLEAANQSL QADLKLAFKR IGDLQAAIED EMESDDNEDL
INSLQDMVTK YQKRKNKIQG DSNTDSEVED HVEGVKSWLS KNKGSTKNLS DDGSLKSFSA
VNVEAKEGKE LKEGKEWKEV NKEGREVETS RPVSVMSSLS YRKRSNLSSK GDALFSQNAE
SEDTLSFCKP KPQASDFQND AYLASSRRKS QVLDGMNDRQ SVISQAYSEA NSQARKGLDS
RWSNFNKEST ISFTAPSRAS TFLGLNPEND AKSNVSLGLS SPLGRHQSTS RLDKGRGSRS
QYSSGPSSPC YSRRFGGCSP GSVSRPDSVA YSSRLSEFDV DIDDSRSVAF TERSAYSPHS
STGRSISMPP PQVRSNFEND AVDNLDVKTV SHRNYLDPDL EKAINEVLSF KPIQFKRRTL
EDSDCEEEKF NNNEADRKDT HSVNSLRRSA SAADCMRPAS SRSSRSSRHR HSSKGKSKKK
KRSHSSDSDS SEDGHRHKSS SKRRSKKSKK KSKRKDESLS SSSSSSSSES ESSSDASTIS
YRSSSSVKRA PARKASSPEV DEEAGSQSET QPLNKKDEKK RKKKVDSLMM KYLYRPESD
//
