ID A0A3Q4GJ38_NEOBR Unreviewed; 582 AA.
AC A0A3Q4GJ38;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Lamin A/C {ECO:0000313|Ensembl:ENSNBRP00000006663.1};
GN Name=LMNA {ECO:0000313|Ensembl:ENSNBRP00000006663.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000006663.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000006663.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; A0A3Q4GJ38; -.
DR STRING; 32507.ENSNBRP00000006663; -.
DR Ensembl; ENSNBRT00000006859.1; ENSNBRP00000006663.1; ENSNBRG00000005177.1.
DR GeneTree; ENSGT00940000157244; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000005177; Expressed in zone of skin and 6 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 2.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR PANTHER; PTHR45721:SF5; PRELAMIN-A_C; 1.
DR Pfam; PF00038; Filament; 2.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 24..362
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 359..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 71..203
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 267..344
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 369..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 66063 MW; 321EE59AE94FF36A CRC64;
METPSQKRTS RSAVSPARIT RLQEKEELCN LNDRLAVYID KVRSLESENA GLRLRISESE
SSVTRDLSGI KTAYETELAD ARKTLDQVAK ERARLQLELS KIKEEHKELK ARNTKKESDL
EAALVRLRDL EALLNSKDAA LSTALGEKRT LEAEVKDLKA QLAKLEVNLA DAKRQLQDEM
LRRVDAENRL QTLREELEFQ KNIYNEVPCF INKIGLDIVA CTRAEVEYPH ADQQLNKTSE
KCVGDLENAR QSADRNSNLV GAAHEELQQT RIRMESLSGQ LSKLQKQLSA SEAKTRELEE
ALTRERDLMR RRLEDKDRDI TEIRARMQQQ LDEYQELLDI KLALDMEIHA YRKLLEGEEE
RLRLSPSPPP TKVTVSRTSA SGHSQTTRVR NSSGMSVSKK RRLHDNDSET SSQASASGRI
TVDEVDLEGR YIRLSNKADE VAEIVHYYTS TPKWGGNSRP RGFRSRPGST HLNQMCWIKD
TSKTCRTNGP QGLEFLTSAI RNISSVFSGL FVTRPNSPTF SYAGPITGQL ASEETGWEFN
PNHLQVSPQV HSEGRRDCDC KLHQAFFLSL PLFRDSVNMF GH
//
