ID   A0A3Q4GKY2_NEOBR        Unreviewed;       303 AA.
AC   A0A3Q4GKY2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Interferon-inducible GTPase 5-like {ECO:0000313|Ensembl:ENSNBRP00000010170.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000010170.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000010170.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. IRG family. {ECO:0000256|ARBA:ARBA00005429}.
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DR   AlphaFoldDB; A0A3Q4GKY2; -.
DR   STRING; 32507.ENSNBRP00000010170; -.
DR   Ensembl; ENSNBRT00000010458.1; ENSNBRP00000010170.1; ENSNBRG00000007934.1.
DR   GeneTree; ENSGT00950000183007; -.
DR   OMA; WNAQLDI; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000007934; Expressed in heart and 6 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR030385; G_IRG_dom.
DR   InterPro; IPR007743; Immunity-related_GTPase-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR32341; INTERFERON-INDUCIBLE GTPASE; 1.
DR   PANTHER; PTHR32341:SF10; INTERFERON-INDUCIBLE GTPASE 5; 1.
DR   Pfam; PF05049; IIGP; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51716; G_IRG; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        158..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        215..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        256..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..126
FT                   /note="IRG-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51716"
SQ   SEQUENCE   303 AA;  34092 MW;  27CAF512B635352F CRC64;
     MLWDLPGIGT TKFPAKKYLK HVKFEKFDFF IIISDTRFRE NDVKLAKEIQ RMKKKFYFVH
     SKIDNDIQAE RRKRDHFIDL YNVNMCFFCD TGLRGLGIES PQVFLVSSFE LHLYDFPLLH
     QTLERELPSN KRDTLLFVMP NINPEIIIKK KKAFKRRLYW LATLSAAVAA VPVPGLSIAV
     DLALLVGAVT HFVHAFGLDI PSLTRLSNRT GVPYADLRAV IISPLAAAEI TAGLLMKVAT
     QVGRTAALIA AEEVSRFIPF IGIPVAMGFS FATTYTILKS ILNELADDAQ KVFEKALGLN
     TSV
//