ID A0A3Q4GM57_NEOBR Unreviewed; 419 AA.
AC A0A3Q4GM57;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Lipase member H-like {ECO:0000313|Ensembl:ENSNBRP00000010640.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000010640.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000010640.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q4GM57; -.
DR STRING; 32507.ENSNBRP00000010640; -.
DR Ensembl; ENSNBRT00000010935.1; ENSNBRP00000010640.1; ENSNBRG00000008271.1.
DR GeneTree; ENSGT00940000166938; -.
DR OMA; KISMRIN; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000008271; Expressed in camera-type eye.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR016272; Lipase_LIPH.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR000734; TAG_lipase.
DR PANTHER; PTHR11610; LIPASE; 1.
DR PANTHER; PTHR11610:SF186; LIPASE H-RELATED; 1.
DR Pfam; PF00151; Lipase; 1.
DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR PRINTS; PR00821; TAGLIPASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000865-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 28..290
FT /note="Lipase"
FT /evidence="ECO:0000259|Pfam:PF00151"
FT ACT_SITE 146
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT ACT_SITE 170
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT ACT_SITE 240
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT BINDING 184
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT BINDING 186
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT BINDING 189
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
SQ SEQUENCE 419 AA; 47030 MW; 12DB459D9E0B962A CRC64;
LCPFFPPGES CDNFTDLDLT HCFVGTSLYV RLLLYTRSNL DCGRELNHRH LSSQPLFNLS
RPTAFVIHGY RPTGAPPIWI NHIVHLLAEQ EDMNIIVVDW NKGAANLNYF TAVSYTREAA
LNLTGFIMTM EAEGASLSSV HLIGVSLGAH LAGFVGANLK GKIGRITGLD PAGPMFTRAT
PEERLDPSDA MFVDVLHTDM NSFGLRGAHG HIDFYANGGA DQPGCPKTIF SGKSYFVCDH
QRSVFLFLCA LNRTCTLTGY PCSSYSDFLD ARCLQCEAFK PASCPVLGGC SSAADKYSLM
YRVDMVTWNQ YLRWGVVYIR LHSGRNVTEA RIDHKLLRFE QYTSTRLLAQ FDEDLQHIQK
ISLRINTGNV IGPRYKIRLL RIRFTPLELP ERPLMCRFDI IMEENIEVAF RPLPCGSRL
//
