ID A0A3Q4GM74_NEOBR Unreviewed; 326 AA.
AC A0A3Q4GM74;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=5'-AMP-activated protein kinase subunit gamma-2-like {ECO:0000313|Ensembl:ENSNBRP00000010076.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000010076.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000010076.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1
CC or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic
CC subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
CC {ECO:0000256|ARBA:ARBA00025878}.
CC -!- SIMILARITY: Belongs to the 5'-AMP-activated protein kinase gamma
CC subunit family. {ECO:0000256|ARBA:ARBA00006750}.
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DR AlphaFoldDB; A0A3Q4GM74; -.
DR Ensembl; ENSNBRT00000010356.1; ENSNBRP00000010076.1; ENSNBRG00000007411.1.
DR GeneTree; ENSGT00950000183019; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000007411; Expressed in zone of skin and 4 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR CDD; cd04618; CBS_euAMPK_gamma-like_repeat1; 1.
DR CDD; cd04641; CBS_euAMPK_gamma-like_repeat2; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR PANTHER; PTHR13780:SF41; 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1 ISOFORM X1; 1.
DR PANTHER; PTHR13780; AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT; 1.
DR Pfam; PF00571; CBS; 3.
DR SMART; SM00116; CBS; 4.
DR SUPFAM; SSF54631; CBS-domain pair; 2.
DR PROSITE; PS51371; CBS; 4.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 43..103
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 122..180
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 197..260
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 264..323
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 326 AA; 36821 MW; 1AE9D1230BC64FA9 CRC64;
MKVEMPNPVQ TVCCDQLVYF LLEADATVYM KFMKSHCCYD AIPTSCKLVI FDTTLQVKKA
FYALVANGLR AAPLWDSKLQ RFVGMLTITD FINILHCYYK SPMVQMYELE SHKIETWRGD
SLQSIPLLIS SPSSLFEAIY SLLRYKIHRL PVIDPESGNV LHILTHKRIL KFLHIFGKKP
PKPAFTKRPI QELGIGTFRN IATVQQTASL YDALSIFVER RVSALPVVDE QGTLYSAVAN
LAAQKTYNNL DMTMQEAVEK RICCVEGVIK CYPYETLDII IDRIVKAEVH RLVLVDRADV
VKGIISLSDL LQAMVLTPAG IDALLS
//
