ID   A0A3Q4GMF6_NEOBR        Unreviewed;       557 AA.
AC   A0A3Q4GMF6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Apoptosis-inducing factor 3-like {ECO:0000313|Ensembl:ENSNBRP00000007938.1};
GN   Name=AIFM3 {ECO:0000313|Ensembl:ENSNBRP00000007938.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000007938.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000007938.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase family.
CC       {ECO:0000256|ARBA:ARBA00006442}.
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DR   AlphaFoldDB; A0A3Q4GMF6; -.
DR   STRING; 32507.ENSNBRP00000007938; -.
DR   Ensembl; ENSNBRT00000008160.1; ENSNBRP00000007938.1; ENSNBRG00000006155.1.
DR   GeneTree; ENSGT00940000160448; -.
DR   OMA; RCTHYGA; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000006155; Expressed in brain.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0072114; P:pronephros morphogenesis; IEA:Ensembl.
DR   CDD; cd03478; Rieske_AIFL_N; 1.
DR   Gene3D; 3.30.390.30; -; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   Gene3D; 2.102.10.10; Rieske [2Fe-2S] iron-sulphur domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR   InterPro; IPR028202; Reductase_C.
DR   InterPro; IPR017941; Rieske_2Fe-2S.
DR   InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR   PANTHER; PTHR43557; APOPTOSIS-INDUCING FACTOR 1; 1.
DR   PANTHER; PTHR43557:SF8; APOPTOSIS-INDUCING FACTOR 3; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   Pfam; PF14759; Reductase_C; 1.
DR   Pfam; PF00355; Rieske; 1.
DR   PRINTS; PR00368; FADPNR.
DR   PRINTS; PR00469; PNDRDTASEII.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF55424; FAD/NAD-linked reductases, dimerisation (C-terminal) domain; 1.
DR   SUPFAM; SSF50022; ISP domain; 1.
DR   PROSITE; PS51296; RIESKE; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT   DOMAIN          70..165
FT                   /note="Rieske"
FT                   /evidence="ECO:0000259|PROSITE:PS51296"
SQ   SEQUENCE   557 AA;  60956 MW;  DB46B1C1EB689D20 CRC64;
     MGGCFSKPKP VEVKVELSLL DKEKEVDGLS PNGKASPFAE CRPNGALAHG SDDDSTLLPL
     YHKPRDYVEA SVCHVKDLEN GQMREVDLGS GRALLIKEHG EFTAMGHKCP HYGAPLVKGV
     LSKGHVRCPW HGACFNIATG DIEDFPGLDS LPIFQVRVEK DKVIIRANKQ ALQSQKRSKP
     MARCSAVINS NTGFSHVLII GSGPASLVCA ETLRQEGFTD RIVMCTMDKH PPYDRPKLSK
     VVAIDVKTQS VIFEDGLRME YRKLFIATGS KPKPMNYKGK DVRNVFHLRT PEDANSIARL
     ANNKNAVIVG TSFVGMEVAA ALTDKAHSVS VIGIESVPFK KALGEKVGKA IMKLFEANRV
     KFYMLNEVSE MVGHHGQLKE VVLKSGKVLR ADVCVIGAGS VPATGFLKQS GIHLDSKGFI
     TVNKNMQTNV DGVFAGGDVV MFPFPPRNNK KVNIPHWQMA HVHGKVAALS MMGRATEVKT
     VPYFWSAMFG KTIRYAGYGD GFDDVIIQGD LDELRFVAFY TRSEEVVSVA SMNYDPIVSR
     VAEVLGSGKT IKKRDVE
//