ID A0A3Q4GMZ0_NEOBR Unreviewed; 779 AA.
AC A0A3Q4GMZ0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Cadherin-22-like {ECO:0000313|Ensembl:ENSNBRP00000008168.1};
GN Name=CDH22 {ECO:0000313|Ensembl:ENSNBRP00000008168.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000008168.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000008168.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
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DR AlphaFoldDB; A0A3Q4GMZ0; -.
DR Ensembl; ENSNBRT00000008398.1; ENSNBRP00000008168.1; ENSNBRG00000006308.1.
DR GeneTree; ENSGT00940000159376; -.
DR OMA; GAWAMHT; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000006308; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF311; CADHERIN-22; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 590..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..140
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 141..249
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 250..357
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 359..463
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 463..580
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 779 AA; 85371 MW; 5F40BC087B78EFF9 CRC64;
MFHSSQGPCL LPPPTLQCLS EVLGGPSSLE RVKRGWVWNQ FFVVEEYTGT EPLYVGKIHT
DSDDGEGNIK YTISGEGAGS IFIIDELTGD IHATERLDRE EKAFYTLRAQ ARDRLSNDPL
EPESEFVIKV QDINDSEPKF LEGPYIGSVA ELSPIGTSVM KVTASDADDP TYGSSARVVY
SVLDGEKFFT VDKNKGIIMT AVADLDRETQ DRYELVVKAT DMAGQMGGLS GSTTVTIVIT
DVNDNPPRFP QKMYQFSVSE GAAVGTPVGR VIATDADMGE NTDMSYLITD GGELFKVTTD
METQEAVPLD FENKRTHNVV VEAVNKHVDP RFVDLGSFRD QTIVLVSVSD TDEPPIFYPA
DGTIMEVQED AKVGALVGIV TARDPDVKNK PVRFSIDRTT DQEMIFHIDP DSGAITLGKI
LDRETAGWHN ITVKAVEADN HTMASQTSVS IRILDVNDNP PELATPYEAS ICEDAKPGQL
IHTISVVDRD EPQTGHRFYF NLAPEASSNR YFSLLDLKDN TAGIRTQRSG FNRHEQNVYF
LPILVVDSGP PSLSSTGTLT IRVCGCDTDG AIQSCNATAY VMSAALSPGA LIALLVCMLI
LIVLVLLILT LKRHRKGQRM TEDEEDMRDN VIKYNDEGGG EQDTQAYDMS ALRNLYDFPE
AKSCDSGPDI RSLPQWIQAK RVGGSGAEAA AAAATDFSLF KGYIRKKVEQ ADADLSVPPY
DSFQTYAFEG TSSPALSLSS IHTLSTTSEQ DFSYLSEWGP RFRQLAGYYA PGNPEEERS
//
