ID A0A3Q4GP29_NEOBR Unreviewed; 887 AA.
AC A0A3Q4GP29;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Tyrosine-protein kinase transmembrane receptor ROR2-like {ECO:0000313|Ensembl:ENSNBRP00000008578.1};
GN Name=ROR2 {ECO:0000313|Ensembl:ENSNBRP00000008578.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000008578.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000008578.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR AlphaFoldDB; A0A3Q4GP29; -.
DR STRING; 32507.ENSNBRP00000008578; -.
DR Ensembl; ENSNBRT00000008829.1; ENSNBRP00000008578.1; ENSNBRG00000006714.1.
DR GeneTree; ENSGT00940000153947; -.
DR OMA; QYLASHH; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000006714; Expressed in testis.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0060027; P:convergent extension involved in gastrulation; IEA:Ensembl.
DR CDD; cd00108; KR; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416:SF132; TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR2; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00051; Kringle; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00018; KRINGLE.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00130; KR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 342..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..91
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 118..245
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 257..335
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 412..685
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 371..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 258..335
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 279..318
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
SQ SEQUENCE 887 AA; 99468 MW; 8B930F0187B0B44C CRC64;
PTVEGYFLEF QEPVNNITLF QGQTATLHCK VAGNPRPSIR WLKNDAPVVQ EQGRLTIRKT
EAGSKLRIQD LDTTDTGYYQ CVASNSVKVI SATGVLYVKL GKTEVYLPKH RFQRFPLPYR
GIACARFIGN RSIYVESLQM QGESENRITA ALTMIGTSTH LSDQCSEFAI PSFCYYVFPL
CDEQSRGPRR RQLCRDECEA LENDLCLAEY TIARSNPMLL MQLKLPSCHL LPQPGTPAAA
SCMRIGVPPE KLGSYHSCYN GSGVDYKGTI SITKSGHYCQ PWSAQYPHSH HLSQEYPELW
GSHNFCRNPG GLMQAPWCFT LDPLVRVDLC EIQPCKNPRK EILFILIPAV AIPLVIACLF
FLVCLCRNKH KASNDTPPRS QLSSSPSQDT ELSPLNHQKQ QAKLREINMS AVRFMEGLGE
DRFGKVYKGH LYGTVPGEQT QVVAIKTLKD KVDSALCEEF HHEAMVRFHL QHPNIVCLLG
VVTKEQPMSM IFTYSSLGDL HEYLVMRSPN SDVGSSDDDK TIKSTLEQAD FIHVITQIAS
GMEYLSSHQI VHKDLAARNI LVFEKLGIKI LDLGLFRDVY SADYYSLMGT SPFPIRWMSS
EAIKHGKFST DSDIWSYGVL LWEIFSYGLQ PYCGYSNQDV IDMVRSHQLL PCPDDCPSWI
YNLMLECWSE VPARRTRFKD IHARLRSWES LSNYNGSAQV SGTSNNTTQT SSLSTSPVSN
LSINTTSASR YTSPKKSSPF HQPQFMPIKG QLHRPMVPPQ LYIPVNGYHP IPAYPYLQNF
YPMQIPMAMP HQQIHHPQQM VTKAGSQHSG SGSTSTGYVT TVPSNTSATE RTAMVNEDSK
ANDEELADGA SEEELNQNED LAVPETELLG ESEAPQTEEL VIHLSDT
//
