ID A0A3Q4GPI2_NEOBR Unreviewed; 1133 AA.
AC A0A3Q4GPI2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Sterol regulatory element-binding protein 1 {ECO:0000256|ARBA:ARBA00039749};
DE AltName: Full=Sterol regulatory element-binding transcription factor 1 {ECO:0000256|ARBA:ARBA00042215};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000005292.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000005292.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Forms a tight complex with SCAP, the SCAP-SREBP complex, in
CC the endoplasmic reticulum membrane. {ECO:0000256|ARBA:ARBA00038568}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SREBP family.
CC {ECO:0000256|ARBA:ARBA00038460}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q4GPI2; -.
DR STRING; 32507.ENSNBRP00000005292; -.
DR Ensembl; ENSNBRT00000005449.1; ENSNBRP00000005292.1; ENSNBRG00000003534.1.
DR GeneTree; ENSGT00940000159156; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000003534; Expressed in blood and 9 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18921; bHLHzip_SREBP1; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR46062; STEROL REGULATORY ELEMENT-BINDING PROTEIN; 1.
DR PANTHER; PTHR46062:SF2; STEROL REGULATORY ELEMENT-BINDING PROTEIN 1; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 362..412
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 73..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1133 AA; 121934 MW; EB378E0FBD3535B5 CRC64;
MNSLSFDDHS LDNLDPTLSL NDPSDIDTAL LSDIDDMLQL INNQDMEFGG LFDAPPYTTA
PPMQEIHGLT QTITSASPPT TTTTPPSSSS ILSSNPHLDA LLGPPITRSS STPDKAFQPP
TFQQSPLAQV PSSTQRQQPS SPQQAQSIRQ TQVEQPQPVL SPSAPSQAAS PNGSPGPNPA
FSSTPQALFT SPAPQTPPQT QTQPQARTNY SSPNSYTAGS PSSVSTPATS LSSSPPSIQP
VAIQAQLQGL TTASPLLTTS TSPPVQTVAA HVQQVPVLLQ PQFIKAESLL LTTLKPDPCM
VTTVASPTSL ATTTPAQSTS LQAFMGGGTF LTTVPVMVDA EKLPINRIAI SGKPVGQPHK
GEKRTAHNAI EKRYRSSIND KIMELKDLVA GTDAKLNKSA VLRKAIDYIR YLQQTNQKLK
QENMALKMAA QKNKSLKDLV AMEVDGQADV KSELPTPPAS DVGSPTSFSH CGSDSEPDSP
MGEDTKPNIG TPDQSTAGGS AVGMLDRSRM ALCTFTFLFL SLNPLAALFC SSGSSSSGNT
EAVSTHHAGR TVLGVDVAGD SWGWMDWMLP TILVWLLNGI LVSGVLIRLL VYGEPVTRPH
SGSSVLFWRH RKQADLDLAR GDFAQASHNL WTCLKALGRP LPTSQLDLAC AALWSLLRFC
LQRLWVGRWL AARAGGLRSD RPLQEDACKS SRDAALVYHR LHQLHMTGKL NGSHLSAVHM
SLSAVNLAEC SGSCLPVASL AEIYVSAALR VKASLPRVLH FTSRVFLSSA RQACLSSSGS
VPPAMQWLCH PLGHRFFVDG DWAIRSTPKE SIYSQAGNTV DPLAQVTQAF REHLLEKALY
CVAQPRGEKN TSCDPHSKWW SSITVVIINW LQGDDAAAER LYPTVEHLPR SLQNAESLLP
KACLNTFRAV RALLSKPENC QLSLSYSDKA SALLRDSLNL GPHCHSSSLD KVVQLLLCDL
LLVMRTNVWR LQQQGATPTG QGSAGTSGPA GIQQASPPEL VGFQQDLSSL RKLAQSFRPA
MRRLFLHEAT ARLMAGASPT RTHQLLDRSL RRRATPGAKT EECEMRPGQR EQAEAVMLAC
RYLPPSFLSA PGQRVGMLAD AARTLEKLGD KRTLHDCQQM IIKLGSGTTV TNS
//
