ID A0A3Q4GQ77_NEOBR Unreviewed; 4481 AA.
AC A0A3Q4GQ77;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Plectin-like {ECO:0000313|Ensembl:ENSNBRP00000011186.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000011186.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000011186.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSNBRT00000011506.1; ENSNBRP00000011186.1; ENSNBRG00000008648.1.
DR GeneTree; ENSGT00940000162855; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000008648; Expressed in muscle tissue and 8 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd00176; SPEC; 2.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 3.90.1290.10; Plakin repeat; 6.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF20; PLECTIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00681; Plectin; 15.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00250; PLEC; 34.
DR SMART; SM00150; SPEC; 4.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF75399; Plakin repeat; 7.
DR SUPFAM; SSF46966; Spectrin repeat; 5.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 35..138
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 151..256
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 794..851
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1493..1551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1566..1705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2079..2136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2408..2432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2470..2492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4432..4481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 12..39
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 747..777
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1239..1290
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1939..2036
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1566..1581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1582..1596
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1609..1700
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2470..2490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4481 AA; 512617 MW; C1480510B5632934 CRC64;
MAMYEPAYLP PNAEEQDFIQ AYENVREKYK DERDRVQKKT FTKWVNKHLI KSQRHVTDLY
EDLRDGHNLI SLLEVLSGET LPREKGRMRF HKLQNVQIAL DFLRHRQVKL VNIRNDDIAD
GNPKLTLGLI WTIILHFQIS DIQVNGQSED MTAKEKLLLW SQRMTDGYQG IRCDNFTTSW
RDGKLFNAVI HKHYPRLINM GKVYQQTNLE NLEQAFSVAE KDLGVTRLLD PEDVDVPHPD
EKSIITYVSS LYDAMPRTDV HDGMRANELE LRWQEYYELV TVLQQWIRHH VMIFEERKFP
ASYEEIELLW RQFLKFKETE LPVKETDKSR SKHIYQSFES AVHAGQVKVP PGYHPIDVEK
EWGRLHVAIL ERERLLRIEF ERLERLQRIC GKVQKESGMC DDQLAHLETL LQTDIRLLNA
GKPAQHAAEV ERELDKADNV IRLLFNDVQV LKDGRHPQAE QMYRRVYRLH ERLVNLRTDY
NLRLKSAVTT AQAPITQSVQ QKGRPELDDV TLRYVQDLLA WVEENQRRID NAEWGSDLPS
MESQLGSHRG LHQTVEDFKS KIERAKADET QLSPVSKGTY REYLGKLDLQ YGKLLNSSKF
RLRNLESLHA FVSAATKELM WLNDKEEEEV NFDWSDRNTN MTAKKDNYSG LMRELELREK
KVNDIQTLGD RLVRDGHPGK KTVESFTAAL QTQWSWILQL CCCIEAHLKE NTAYYQFFAD
VKEAQDKMKK MQENMKKKYS CDRSTTATRL EDLLQDAAEE KEQLNEFKTV VAGLNKRSRS
IIQLKPRNPT TSIKGKLPIQ AVCDFKQQEI TVHKGDECAL LNNSQPFKWK VLNHSGHEAM
VPSVCFIVPP VNKEALDGVS SLDAGHQGMV SMWQMLHINM KSLLSWQYLM RDFTQIHSWN
ITMLKTMKPE EYRLIMRNLE LHYQDFMRDS QDSQLFGPDD RMQVEDDYTK STQHFDNLLR
SMEKGIMVVR VKGQQNETLC KNYISELKDL RLRIEDCEAG TVARIRKPVE KEPLKECIQK
TTEQKKVQGE LDSLKKDLDK VSVKTQEVLA SPQPSASAPV LRSELDLTVQ KMDHAHILSS
VYLEKLKTVE MVIRNTQGAE GVLKQYEDCL REVHTVPSDV KEVETYRAKL KKMRTEAEGE
QPVFDSLEEE LKKASAVSNK MARVHSERDV ELDHFHQQLS SLQDRWKAVF TQIDLRQREL
EQLGRQLGYY RESYDWLIRW IADAKQRQEK IQAVPITDSK TLKEQLAQEK KLLEEIEQNK
DKVDECQKYA KAYIDTIKDY ELQLVAYKAQ VEPLVSPLKK TKLDSASDNI IQEYVTLRTR
YSELMTLTSQ YIKFITDTQR RLDDEEKAAE KLKAEERKKM AEMQAELDKQ KQLAEAHAKA
IAKAEKEAQE LKLKMQEEVS KREIAAVDAE KQKTNIQLEL QELKNLSEQQ IKDKSQQVDE
ALHSRTKIEE EIRIIRIQLE TTQKQKYTAE SELQQLRDRA AEAEKLRKLA QDEAEKLRKQ
VSEETQKKRQ AEEELKRKSE AEKEAAKQKQ KALEDLEKLR MQAEEAERQV KQAEIEKEKQ
IKVAHQAAQQ SAAAELQSKH VSFAEKTSKL EESLKQEHGA VLQLQQEAER LKKQQEDAEN
SREEAEKELE KWRQKANEAL RLRLQAEEEA HKKTLAQEEA EKQKEEAERE AKKRAKAEES
ALKQKEMAEE ELERQRKIAD STAQQKLTAE QELIRLRADF DNAEQQRSLL EDELYRLKNE
VAAAQQQRKQ LEDELAKVRS EMDILIQLKT KAEKESMSNT EKSKQLLEAE AAKMKDLAEE
ASRLRAISEE AKHQRQIAEE EAARQRAEAE RILKDKLAAI SEATRLKTEA EIALKEKEAE
NERLRRQAED EAYQRKALED QANQHKQEIE EKIVQLKKSS EAEMERQKAI VDDTLKQRRI
VEEEIRILKL NFEKASSGKL DLELELNKLK NIADETQQSK IRAEEEAEKL RKLALEEEKR
RREAEEKVKK IAAAEEEAAR QRKVALEELE RLRKKAEEAR KQKDEADKEA EKQIVVAQQA
AHKCSAAEQQ VQSVLAQQIE DSITQKKLKE EYEKAKKLAK EAEAAKEKAE REAALLRQQA
EEAERQKAAA EKEAANQAKA QEDAERLRKE AEFEAAKRAQ AEASALMQKQ QADAEMAKHK
MLAEQTLKQK FQVEQELTKV KLKLDETDKQ KSVLDEELQR LKDEVDDAVK QRGQVEEELF
KVKVQMEELL KLKNKIEEEN QRLIKKDKDS TQKLLAEEAE NMRKLAEDAA RLSVEAQEAA
RLRQIAEDDL NEQRALAEKM LKEKMQAIQE ASRLKAEAEM LQKQKDLAQE QAQKLLEDKQ
LMEQRLEEET EEYQKSLEVE RKKQLEILAE AERLRLQVSQ LSKAQARAEE DAGDLHKAIA
GLENEKARLK KEAEERQNKS KEMADAQQKK IEHEKTVLQQ TFMTEKEMLL KKEKLIEDEK
KKLESQFEEE VKKAKALKDE QERQKQQMEQ EKKTLQATMD AALSKQKEAE EEMLRKQKEM
QELERQRLEQ ERILAEENQK LREKLQQLED AQKDQHTRET VRHKDVIHLT TIETTKTVYN
GQNVGDVVDG IDKKPDLLAF DGIRDKVPAS RLHELGVLPK KEFDKLKNGE TTVEELGKTD
SLRSILKGKN AIGGVLTPSN QKMSIYQASK EKKITPGTAM ILLEAQAATG YMLDPTKNQK
LSVNAAVKEG LIGPELHNKM LLAERAVVGY KDPYTGGKIS VFEAMKKGLI EHDHAIRVLE
AQLATGGIID PINSHRVPTE TAYKQGHYDA EMNKIMENPS DDTKGYFDPS TQEPLTYSEL
MARCTTDPET SLLLLPITDK AAQCSSIYTE EETKDVFGKT TVSVPFGRFK GKTVTIWEII
NSEYFTEDQK KDLLRQYKTG KITIEKIIKI VITVAEEKEK KNEITFDGLR APVPATDLLE
SKIIDKDLYN KLHNGNMTVS EVSQMEPVHK ALKGTNCIAG VVIDSSKETM SFYQAMKKDM
MRPGPALNLL EAQAGTGYLV DPVHNQKYTD DEAVKAGVVG PELHEKLLSA ERAVTGYRDP
YTGKAVSLFQ AMKKDLIPKE QGLRLLDAQM TTGGIIDPVK SHRIPHDVAC KRNYFDDEMK
QALSNPNDET KCFFDPNTKE NLTYSQLFDR CVTDKKTGLR VLPLSDEAIN AKEQPAYTEA
LTKEAMTQAT VEVNSGPFKG RKMTLWEIIN SEYLTEEERL DLLRQFRSGK ITIEKIIKII
ITIVDEKEAK KQEQSSFKGL RAPVPADSLY ESKIIDKPTF DLLQQGKTTP KKVSENPNVS
KYLQGSSSIA GLYLKPTKEK LSIYQAMKKK LLRHNTGLSL LEAQAASGFI VDPVRNQCLS
VDEAVKSGVV GPELHEKLLS AEKAVTGYKD PFTGNKISLF EAMQKDLILK EHAMPLLEAQ
IVSGGIIDPV KSHRVPTDVA YQKNILSRDI AKTLSEPCDE NKVFSDPETD ETITYRQLKD
KCQKDKDTGL YMLSLSKPQS PTVVEKTYLY TEEQTQSELS GTQLDIPIEG LADKPINLWD
IMNSNLLPEQ ERQKLLDEYR SGKITKERMI IIIIEIMEQR EIIRNDNPLS YMTIRRRITI
EELYNARIID LETYNLLKQG KRDIRNIMEL TSVKQYLYGT GCVAGVTTDS SSKLSIYQAM
KRGFIKPEIG LTLLEAQAAT GFIVDPLKNE TLTVDEAVRK GVVGPEIHDK LLSAERAVTG
YKDPYSGKTI ALFQAMKKDL VPEDYALKML EAQTATGGII DPEFQFHLPT DVAMQRGYIN
KETNEKLNDD VKGFIDPVTD EKLSYAQLLK RCKLDGGLRL LSLGDQRLTF KGLRKQITIE
ELIRSQIIDQ QTVTDLNEGL VSVEEISNRL SRYLQGTGCI AGVFLESTKE RLSIYQAMKK
NMIRPGTAFE LLESQAATGY VIDPIKNLKL TVNEAVKMGI VGPEFKDKLL SAERAVTGYR
DPYTGKTISL FQAMKKGLIL KDHGIRLLEA QIATGGIIDP EESHRLPVEV AYNRGFFDEE
MNEILTDPSD DTKGFFDPNT EENLTYLQLM ERCITDPDTG LVLLLLKEKK RERKTSSKSS
VRKRRVVIVD PETGKEMTVY EAYRKGLIDH QTYLELAEQE CEWEEITMTS SDGTVKSVII
DRKSGRQYDV DDAIARGFID QKALETYRAG NLSITEFADL LSGNMGGFRS RSSSFGSTTG
STYSSSMSPL PTIKPPAVIW NDPTEETGPV AGILDIDTLE KVSVTEAIHR NLVDNITGQR
LLEAQACTGG IIDPTSGERY SIAEATEKGL VDKVMVDRLN LAQKAFNGFE DPRTKVKMSA
SQALKKGWLY YEAGQRFLEV QYLTGGLIEP DVEGRVSIDE SIRKGTIDAR TAQKLRDVSA
YSKYLTCPKT KLKISFKDAM DKSMVEEGSG LRLLEASSQS SKGLYSPYNA SGSGSAYGSR
TGSRTGSRSG SRRGSIDAGS GFSMNFSSSS FTSSSGYSRR F
//
