ID A0A3Q4GQF3_NEOBR Unreviewed; 981 AA.
AC A0A3Q4GQF3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Protocadherin-8-like {ECO:0000313|Ensembl:ENSNBRP00000011975.1};
GN Name=PCDH8 {ECO:0000313|Ensembl:ENSNBRP00000011975.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000011975.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000011975.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q4GQF3; -.
DR STRING; 32507.ENSNBRP00000011975; -.
DR Ensembl; ENSNBRT00000012313.1; ENSNBRP00000011975.1; ENSNBRG00000009336.1.
DR GeneTree; ENSGT00940000155219; -.
DR OMA; HEDSYMI; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000009336; Expressed in camera-type eye and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF46; PROTOCADHERIN-8; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..981
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018627727"
FT TRANSMEM 701..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..140
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 141..249
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 250..357
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 372..468
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 469..584
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 584..688
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 731..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..870
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 981 AA; 107953 MW; 6B6154DD5A6DBB3F CRC64;
MSPVCKFKTY WHRWILIFSI HQFLFASWAR SEGNTIRYQT NEENAPGTVI GNLAKDMSLS
LSHSSKSNFR MMKQFNDSFI RVRESDGELT VGERVDRERI CRHSLQCLIT FDVVNFSKDR
YKLIHVEVEI KDINDNSPEF PSKESIVEIS ENAAVGSRVP LDPAVDADVG SNYIQSYQIS
VNSHFTIDVL LRADGVKYAE LVLMKELDRE TQSSYTVELV ATDGGNPYRS GSTKITIKVT
DFNDNSPVFD QNSFSVSLPE DAPVGTVILD LNAVDADEGL NGEVVYGFGK QVSHEIRQLF
QVDNKSGRLT LRGPVDFEDK STYELDVQAT DLGPNPTPSV CKIIIHVTDV NDNAPEISIT
PMTSITTGIA YISEAADKDS LVALISTMDR DSGVNSQVYC TLYGHDHFKL RQAYEDSYMI
VTAAALDRER ISEYNLTVMA EDFGSPPLRK ITQYTIRLTD ENDNAPHFAK AVYEVSVVEN
NAPGAYITTV EATDADLGNN GKITYRLVES VIMGSPVNTF VSLNSVSGSI YALRSFNYEV
MKQLDVHIQA SDGGSPQLQS RAVIRLKIVD QNDNQPSIIE PPLYKGSAEV FLPKDAPAGY
VVTQIKATDA DEGINAQLSY KITEGGHLGF SINKDTGKVH VSRQLTYDIA DNVKVTVSVA
DNGSPALTST ATIHFSFVEG ALPSSPSSAQ NGNEEPFEWD MSVAIIIVLA GSCSVLLVAI
ILITTICSRR KKETGDGGSD DKEEIPNVEK VESGHIDSLN QNHKGKVFDA HPFPENPPLA
SSNTMETGCE DGRQTPGMFD SNNRVMEGKL KGYSTLPGYG KETVRPITIW KGNSFTTISA
RDPHISGKDS GKGDSDFNDS DSDISGDVHK KESPPTNSLW ACTNECKVLG HSDRCWSPSA
TRPNTSLACG PHLSTFSKTA SLPRDTRREN YYPPHMPKTS GLQSVYEKVQ HQEFDYILVG
PPTPARIQET DEISIPEYTK T
//
