ID A0A3Q4GQP5_NEOBR Unreviewed; 805 AA.
AC A0A3Q4GQP5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 1-like {ECO:0000313|Ensembl:ENSNBRP00000005732.1};
GN Name=FARP1 {ECO:0000313|Ensembl:ENSNBRP00000005732.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000005732.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000005732.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR AlphaFoldDB; A0A3Q4GQP5; -.
DR Ensembl; ENSNBRT00000005908.1; ENSNBRP00000005732.1; ENSNBRG00000004166.1.
DR GeneTree; ENSGT00940000155318; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000004166; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17189; FERM_F1_FARP1; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF2; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 41..321
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 805 AA; 89841 MW; D4AC6F8CB786729B CRC64;
MVEPADRSST AGQRLGAPES FGVSTLEPGL RPPAQPPGRQ VSMRVQMLDD TQEVFQISQR
SPGKVLFDLV CAHLNLVEGD YFGLEYQDQR KMTVWLDLLK PTLKQIRRPK NTILRFVVKF
FPPDHTQLME ELTRYLFALQ IKRDLACGRL ICNDTSAALM VSHIIQSEIG DFDETQSWQH
LLHNKYLPDQ DAIRDEIIDC HREHVGQTPA VSDYQLLEIA RRLEMYGVRL HPAKDREGTK
LSLAVANSGV LVFQGNTKIN SFNWSKIRKL SFKRKRFLIK LRADPTNAHH DTLEFAMASR
DCCKVFWKIC VEYHAFFRLF EEPKPRPKPI LFTRGSSFRF SGRTQKQIID YVKDSEPKKV
PFERKHSKIL SNSSMSPQSA STRSHVNPLL MTPTTINPTQ PRQNHHVAGS VLDQQLLNPG
PSCRANKGSS SSIPYIDCSD IDSECDVTKN NRATRGHSNA NDSNEDEPCA YSRHLGSPGR
NGGQAGRLFG AVNGFYHTNH QGLMQQGMVG KQQQNEDVLT NGRLPLHSTL LDEIFQGRDK
RGAVLGRPLG TGTRSQCSSP VISSFHHRTN SLSHSEMTNG HSQPRSASRW DDGGHYFSKR
PGAYSPIASN RTSPNLAKPY YNNNNMRNRS DTDPFILSQL TSTPINHRNR SGVHAKTPGS
APLERRMVMT NGNDRNLLVP GQPRSNTVQR MFGRQGKPGS SPSNNKHNTL NQPVQMIDGS
TSSGTDTSDT ESDTGSSAYS QPLMYGNPAA VSSMISVNSN GTSPLSHTKF SFGSLQLEEG
GDGEEEEEGC YRFNEEDIGG RVFSC
//
