ID A0A3Q4GRF4_NEOBR Unreviewed; 877 AA.
AC A0A3Q4GRF4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Toll-like receptor 5-like {ECO:0000313|Ensembl:ENSNBRP00000006027.1};
GN Name=TLR5 {ECO:0000313|Ensembl:ENSNBRP00000006027.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000006027.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000006027.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR RefSeq; XP_006809178.1; XM_006809115.1.
DR AlphaFoldDB; A0A3Q4GRF4; -.
DR STRING; 32507.ENSNBRP00000006027; -.
DR Ensembl; ENSNBRT00000006213.1; ENSNBRP00000006027.1; ENSNBRG00000004763.1.
DR GeneID; 102781443; -.
DR CTD; 403138; -.
DR GeneTree; ENSGT00940000162464; -.
DR OMA; AQSRYFC; -.
DR OrthoDB; 4633557at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000004763; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF525; TOLL-LIKE RECEPTOR 5; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 5.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..877
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018707524"
FT TRANSMEM 650..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 701..846
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 854..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 877 AA; 100684 MW; E80863C596457D35 CRC64;
MWMLVLQLIC TGLCLKVTVS YQTCRLRGQR AWCGFQNHSW VPALPHNITH LYLQSNHISE
VNSTSLRDFK ELQVLNLEGQ DQTLVIWNNA FLGQRKLTEL MLGSNLGLKL QPRAFAGLFN
LQNLSLYYCS LTDSILSESY LEPLLSLEVL DLSFNNITRL RPGLFFSRFT KFTQLKLKLN
KIENICEEDL VSFRGKRFEL LSLDSNKLYH NDEWGNCGNP FKELAFDVLD LTSSGLHVNE
TRQFFQAIEG TPISHLKYSG ILGKGFSHEN FPDPDKNTFE GLKNSAVKIL DVSNNRIFAL
QSAVFSHLRD AKKIDISLNR INQINRNAFD GLQDHLLILN LSSNLLGQIH SHTFTNLREL
RMLDLSQNHI GILGYKAFSG LPNLQYLDLT SNSLRELGFP TPLPNLEYLL LRDNKLKSLN
EIDDLAMNSI HVDISENRLT NMEDVFFILT YLPRLQVLFY GDNIIKWCKR NYVFEPLNNS
LKVLDLHDSS LQIIWAQGQC LDLFDHLENL IGLNISLNSL TTLPNGIFRG LSSIIEMDLS
YNALTFLQPD VFPISLKWLH ISNNFLASPD PMTFQSLSVL SLSATRFHCD CNLGNFLEWL
NTTNVTFLSP IEDLRCEFPA AFQGLPLLNY STIIEPCETD PEQAVRGLKF AVFLFSASLI
ITVLLTGIIY ARLRGQIFII YKKIISRVLK GPKLMPLEDE MRYDVFICFS NRDYRWVEAA
LLKKLDNQFS EENLFHGCFE ARDFLPGEDH LSNIRDAIWS SRKTLCIVSK DFLKDGWCLE
AFTLAQGRML EELTNVLIML VVGKVAHYQL MKCNAVRAFV QRKEYLTWPE DPQDMEWFYE
RLISDILKDS KVKKLKEDKP EPGGPEVQPE NIKETSM
//