ID A0A3Q4GRR0_NEOBR Unreviewed; 1310 AA.
AC A0A3Q4GRR0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Double-stranded RNA-specific adenosine deaminase-like {ECO:0000313|Ensembl:ENSNBRP00000006142.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000006142.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000006142.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSNBRT00000006329.1; ENSNBRP00000006142.1; ENSNBRG00000004510.1.
DR GeneTree; ENSGT00940000157243; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000004510; Expressed in testis and 7 other cell types or tissues.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd19915; DSRM_DRADA_rpt3; 1.
DR Gene3D; 3.30.160.20; -; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR044457; ADAR1_DSRM_3.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR042371; Z_dom.
DR PANTHER; PTHR10910:SF107; DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 3.
DR Pfam; PF02295; z-alpha; 2.
DR SMART; SM00552; ADEAMc; 1.
DR SMART; SM00358; DSRM; 3.
DR SMART; SM00550; Zalpha; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 3.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 3.
DR PROSITE; PS50139; Z_BINDING; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 249..315
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 412..477
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 595..663
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 697..765
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 820..888
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 954..1286
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1287..1310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1310 AA; 143482 MW; 58BB477F5C676D73 CRC64;
MSRGRGGPSK EHYYRHPQPR VQERDNIYRP GPGVFYPRAG PQQIAHPSYY DGPTHPEAHI
QPSSPLIPST PPTPSHIKVV PNSVTHNSLY SPNHGAGPSP NSFYDKQREF LTGRISEAPQ
FRATVSGGGG GGFVPNRSHS TIYQPQSGYC RYPNSSPWGR GASQDWRPYR PGAGASRGNL
APRHLNQNQF QGKNHNQHSS RQWRTQTDSL CDQFQGLLLK DRPNRGGERF DKHSSSSSTG
NLSFCKPNIT LTTQIQGEVH EALAALKPGE SISAKVLARK LHLPKKVVNK ALYSLEHLQK
ASKQGLTPPE WTLYREPLRV EEDQSTKYHV QNQPPYSLAS SEPPQKPEAK VETETEEEVQ
AKEEDSDTES SSSYSSSLEF SDSEDSQSSA KGQHHKKQHP STSSSPDQDI KGAVMAEQKE
QIFKYLLQSR EATALNIAKN IGLKTAKQVN STLYALEKQG EVVRNVEVNP PTWELSTHRR
ERMERSLKAA QSNPAVLVKM EVEEEEVSAI FSPSPLPPLP GLEVLTGGWI PDQILSEPLS
SASCKSENAN EGQWSTDDIP EFLNKTNAMG TVAVSVAAPP PQNLWAKLQE VRLKNPVSGL
MEYAQYLGQN CEFLLLDQSG PSHDPRFRMQ VMLNGRLFPV AEASSKKVAK KDAAAATLRI
LVKEMQGGTC DGATSRHQWT AEGPRQPLSR SLPGGKNPVS VLMEYSQRSG KPIEFINTGQ
AGPPHDPRFM YRVKVGESLF AEASAPNKKA ARQLAAEEAV KELMADGKLQ LNKLPLGPSS
GSDESFSGAT CPSLPPLTAD ELRAAHEAGV GDLINHLNNN AVSGLLEYAR ARGFAAEIRL
VGQSGPPHDP KFTYQAKLGG RWFPPVCASN KKQGKQEAAD AALRVLIGEA ERAARTGELT
PLPVSGSTLH DQIAMLSHQR FNALTTRIQH CLLGRKILAT IIMRRGEGLG TVVSLGTGNR
CVKGEELSLK GETVNDCHAE IISRRGFIRF LYSELLKHYE GADDSIFEPA ENNKLRIKSD
ITFHLYISTA PCGDGALFDK SCSEAGDEAQ GHQPLFENAK QGKLRTKVEN GEGTIPVESS
AIVPTWDGIQ HGERLRTMSC SDKILRWNVI GLQGALLTHF LDPIYLKSIT LGYLYSHGHL
TRAVCCRLAR DGEAFTQSLP APFKLNHPEV GRVSVYDSTR HTGKTKESSV NWSFPDQHSV
EVLDGTKGKV DGTKLAVSRV SKSNLFHLFR SLCQRSGRTD LLSLPSYAQA KMSAVSFQQA
KQQFFQALSA HGYGAWIGKP LEEKSFEAGE GNRNNGAPVG NSNNVGAVEA
//
