ID A0A3Q4GSW2_NEOBR Unreviewed; 640 AA.
AC A0A3Q4GSW2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000006612.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000006612.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|ARBA:ARBA00023340};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684;
CC Evidence={ECO:0000256|ARBA:ARBA00023340};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC ERF2/ZDHHC9 subfamily. {ECO:0000256|ARBA:ARBA00023463}.
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DR AlphaFoldDB; A0A3Q4GSW2; -.
DR STRING; 32507.ENSNBRP00000006612; -.
DR Ensembl; ENSNBRT00000006809.1; ENSNBRP00000006612.1; ENSNBRG00000005159.1.
DR GeneTree; ENSGT00940000156001; -.
DR OMA; LAPRYMG; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000005159; Expressed in blood and 8 other cell types or tissues.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR12349; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR12349:SF3; PALMITOYLTRANSFERASE ZDHHC5; 1.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU079119};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU079119};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 29..54
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 60..81
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 161..185
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 197..222
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT DOMAIN 115..234
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
FT REGION 303..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 640 AA; 68785 MW; 2FDC5B6DE9197145 CRC64;
MPGFSSGGVG GGVGGVASAP PRPFRPSRYV PVSAATTFLV GATTLFFCFC PWLSEHFSSV
IPIYNGVIFL FTLANFCMAT FMDPGIFPRE EDEDKEDDFR APLYKTVEIK GIQVRMKWCS
TCRFYRPPRC SHCSVCDNCV EDFDHHCPWV NNCIGRRNYR YFFLFLLSLT THIMNVFGFG
LVYVLHHQQE LDTPGAAVMG VMCVAGLFFV PVAGLTGFHI VLVARGRTTN EQVTGKFRGG
VNPFTNGCLR NITHVLCSSQ APYIGRWRGR QMMEVQPPFL RPALTEAQLE AKVLDNGIQN
SKSSLDQMES QSADAEAPPP PKPELRYPGL PRADTESSLL TEAPPTPSMY KYRPTFNSPG
RNHTALTHPN KMIRGESLDS PSPSILQSSR QPSYRSEPSS LDGTTVVGGG VGVRRGGGER
GEGPGGPGGT AGGVLGGMSG YSLTGRSYTS YPSSLVLSTG GSHSSSLRSA HTAHNPLATL
HSEGTTDTSY KSLANQTPRN GSLSYDSLLT PSESPEFESA AHELSPQKLH APFLSSAVRG
QTEVVSPSTP LQGYTSPFLS AQIAQQREGQ LLQGSATFSS PHKAYLRAVS PPLPSSAGPL
ETHHLLSTSR PVLANHTTSK PGGGVKKVTG VGGTTYEISV
//
