ID   A0A3Q4GV87_NEOBR        Unreviewed;      1635 AA.
AC   A0A3Q4GV87;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Dedicator of cytokinesis protein 3-like {ECO:0000313|Ensembl:ENSNBRP00000011118.1};
GN   Name=DOCK3 {ECO:0000313|Ensembl:ENSNBRP00000011118.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000011118.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000011118.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00983}.
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DR   STRING; 32507.ENSNBRP00000011118; -.
DR   Ensembl; ENSNBRT00000011430.1; ENSNBRP00000011118.1; ENSNBRG00000008455.1.
DR   GeneTree; ENSGT00940000155514; -.
DR   OMA; CTWADIR; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000008455; Expressed in brain and 2 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.25.40.410; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR   InterPro; IPR027007; C2_DOCK-type_domain.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR026791; DOCK.
DR   InterPro; IPR043161; DOCK_C_lobe_A.
DR   InterPro; IPR032376; DOCK_N.
DR   InterPro; IPR042455; DOCK_N_sub1.
DR   PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR   PANTHER; PTHR45653:SF4; DEDICATOR OF CYTOKINESIS PROTEIN 3; 1.
DR   Pfam; PF14429; DOCK-C2; 1.
DR   Pfam; PF16172; DOCK_N; 2.
DR   PROSITE; PS51650; C2_DOCK; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT   DOMAIN          356..520
FT                   /note="C2 DOCK-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51650"
FT   REGION          1337..1380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1495..1517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1341..1374
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1635 AA;  187919 MW;  720D3703AFACEB71 CRC64;
     MFDKCQSVCS CYHFLCLPRI SSFPVSLILS TVICNFRGSV TQGLALEVGE TVQILEKCEG
     WYRGFSTRKP NVKVSQKHKV DLFYKVRHVM MELIDLRRQL LSGHLTQDQS RDVKRHITVR
     LDWGNEHLGL DLVPRKEFEM VDEDQISVSD LYKMHLSSRH SVQQSTTQGD NARQRHGEPC
     RVPVPHHLLV NLKSFTYNSI GEDTDIFFSL YDLREGKTLS EKFMVRLNKN GGPKNPEKVD
     RLCALFTVTT HTRLMKLVVR RLKISDLFFL LFLFVFLSDV VCNNENEWYQ IHENIIRKSS
     TKYTAPSTNY GLIISLQLLR GDMEQVRREN PLIFSRGVAI TRKLGFPDVI MPGDIRNDLY
     LTLERGDFER GGKSVQKNIE VTIYVLYADG EILKDCISLG SGEPNVPEHR SFVLYHNNSP
     RWSEVIKLPI PIDRFRGSHL RFEFRHCSTK DKGEKKLFGF AFTPLMREDG TTLSDESHEL
     YVYKVSYTFL FPGCCSSAFI TRQSFILQRS RTFFTATVNH DSFSVHFRVT RASHSLITVS
     VSQVFIINLL RDSKYYHFRP VMDTYIQKHF AGALAYKELI RCLKWYMDRS AEVVRQDHIQ
     EAMRALEYLF KFIIQSRILY SRATCGMEEE QFRTSVQELF QSIRFVLSLD SRNSETLIFT
     QAALLNSFPA IFDELLQMFT VQEVAEFVRG TLGSMPSTVH IGQSMDVVKL QSIARTVDSR
     LFSFPGKCLD SFINVAQNME RLRYCTSLIN SSVRVDALEK SGEYVSCLLS LLRQMTDIHF
     QHLMENFQSK DELKEFLLKI MCVFRNLMKL SIFPRDWNIM RLLTSNIILT TVQYLSPALH
     KNFTEADFDF KVWNSYFSLA VLYINQPSLQ LENLSPAKRK KVLDKYGDMR VMMTYELFSM
     WQNLGENKIH FIPGMIGPFL GVTLVPQVEV RNIMIPIFHD MMDWEQRKNG NFKQVEAELI
     DKLDSLVSEG KGDENYRELF GLLTQLFGPY PRYDTPCTWA DIRLNQCINT GSALIVCFVS
     SQNFYKSEIN KEEMYIRYIH KLCDMHLQAE NYTEAAFTLL LYWELLHWDE RPLKEFLHYP
     AQTEWHRKEG LCRKVIHYFN KGKVRALTLT YLLFPPVQHP HYPLEGSLGH PPKIVNAAQF
     YTHFYKVTVI NRFKRESTDF YRVNNVRRFR YDRPFHKGPK DRDNEFKVRQ EVLFPLILKI
     YTNSPGIIFT NNSEISCMLF LDALVGPALK SHDKKIMHIK VKQCFYVSLQ GLPGLDKSGS
     GPNTPRGILA THGPMSPESF KLMHRHSPIA VLTPVRNSSS SLSSHNSSEM GNVGNLLILA
     DGMVVEHPED FYRMQVSEKR DSQRGNASLS SSSLSSTHSA PSQMINSAPS TIRVGSPSLP
     DKYRHNREML MLLPPHRERP SSAMYTNITD NGQPPNFQRA LFHQVIGPCK PCSDPNLSVA
     EKGQHLSMHF DAFHHQVSDL PPALPARLLQ MIILILIAPA PVRYSVSEPE VLDGVKPPPC
     RSHSAPGGVT PAQAGSQIQP QAPGLASIGV QQMQQQDALP HPQHPHYYHQ LHHHFHPHYI
     PHHPPLYHLH EPPALPPKPY LREGCIPEED SLISQSAAPP PPAPRPMPRK ISQPIIAATK
     DEQAKVAWEH GIGEE
//