ID A0A3Q4GVF3_NEOBR Unreviewed; 766 AA.
AC A0A3Q4GVF3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Centromere/kinetochore protein zw10 homolog {ECO:0000313|Ensembl:ENSNBRP00000013151.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000013151.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000013151.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}.
CC -!- SIMILARITY: Belongs to the ZW10 family.
CC {ECO:0000256|ARBA:ARBA00006245}.
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DR RefSeq; XP_006785137.1; XM_006785074.1.
DR AlphaFoldDB; A0A3Q4GVF3; -.
DR STRING; 32507.ENSNBRP00000013151; -.
DR Ensembl; ENSNBRT00000013522.1; ENSNBRP00000013151.1; ENSNBRG00000010068.1.
DR GeneID; 102783272; -.
DR CTD; 9183; -.
DR GeneTree; ENSGT00390000016427; -.
DR OMA; TWPRMSE; -.
DR OrthoDB; 2786073at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000010068; Expressed in testis and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:InterPro.
DR Gene3D; 1.10.357.150; -; 1.
DR InterPro; IPR046362; Zw10/DSL1_C_sf.
DR InterPro; IPR048343; ZW10_C.
DR InterPro; IPR048344; Zw10_middle.
DR InterPro; IPR009361; Zw10_N.
DR PANTHER; PTHR12205; CENTROMERE/KINETOCHORE PROTEIN ZW10; 1.
DR PANTHER; PTHR12205:SF0; CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG; 1.
DR Pfam; PF20666; ZW10_C; 1.
DR Pfam; PF20665; Zw10_middle; 1.
DR Pfam; PF06248; Zw10_N; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 27..118
FT /note="Centromere/kinetochore protein zw10 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06248"
FT DOMAIN 176..407
FT /note="Centromere/kinetochore protein zw10 middle"
FT /evidence="ECO:0000259|Pfam:PF20665"
FT DOMAIN 460..589
FT /note="Centromere/kinetochore protein zw10 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20666"
SQ SEQUENCE 766 AA; 86631 MW; 8BE2163D01104DA8 CRC64;
MASFVTEVLA SSGKLEKEDL SGKISKMSRK VEDTKEEVCD MINKRYNDFL PSLQSSEELM
LQVDTVSKEM DTLKNCIENE VQNVHVAVAE YTKLKQQLEK NTVIITMLGH LKEFHSAMEE
FNKALLEKKY VDAANRLERA RKSVGSLKRW KTSELPLLSA LSSELTVQRE NLIYHLGDEW
KRLVIWKLPS TKEPAGEMSF LKVELKLSSA CSKDGELKPP TLLSSVLQAL AIQGDLQHKI
KLFSQVLLKN MLKPLVMYAS LSVRVTEQQG EGTTLALQCL EESDEERCAP SKVYNKLLLV
LKTLHSHLLD VSIGDKKLSA ILGELIWEEM SHTIIHDCLV HSIPTNSSQL EKYNTVIKET
EEFEKSLKEM EYLQGDSTDL LKYARDVNCH FASKKCKDVI VAARKLMTSK MHNTVKITPD
SKLRLPKLPA PSSEGKVKPE SLKEEVTMEN SKQLSAWSLR LPACRISESV QQLMELALDT
LCEAVGSSTQ SALQLFFTVR NIFQLFYDVV PTYHKENLLK FPHLAAIQHN NCMYLAHHLL
TLGHHFRNHL PQPLSEGVAT FVDMVPGFRK LGAQCFLAQL NVQRAELLER LSTAHNFCNL
DDEDNYTAAS KAVRQVIHQL KQLGTVWQDV LPVSIYCKAM GNLLNTAITE VTAKVMMLED
ISSEDGNHLQ TLCQTIIDEG PLVFIPLAEE KKNKKYQEEV PLYVKKWGTF KELVIVLQAN
LQEIVDRWAD SKGPLALEFS SSEVKNLIRA LFQNTERRAA ALAKIK
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