ID A0A3Q4GVY4_NEOBR Unreviewed; 1140 AA.
AC A0A3Q4GVY4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Nidogen-1-like {ECO:0000313|Ensembl:ENSNBRP00000014135.1};
GN Name=NID1 {ECO:0000313|Ensembl:ENSNBRP00000014135.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000014135.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000014135.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q4GVY4; -.
DR Ensembl; ENSNBRT00000014520.1; ENSNBRP00000014135.1; ENSNBRG00000010721.1.
DR GeneTree; ENSGT00940000156318; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000010721; Expressed in testis.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00255; nidG2; 1.
DR CDD; cd00191; TY; 1.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR003886; NIDO_dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR46513:SF6; NIDOGEN-1; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR Pfam; PF06119; NIDO; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00135; LY; 5.
DR SMART; SM00539; NIDO; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF54511; GFP-like; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51120; LDLRB; 3.
DR PROSITE; PS51220; NIDO; 1.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Secreted {ECO:0000256|ARBA:ARBA00022869}.
FT DOMAIN 62..224
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT DOMAIN 319..359
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 363..598
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000259|PROSITE:PS50993"
FT DOMAIN 653..696
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 697..736
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 744..817
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REPEAT 884..926
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 927..969
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 970..1014
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 235..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 787..794
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 1140 AA; 126794 MW; 6787B9860B70C5EC CRC64;
QSWDRFGDWP ILAFIVCRAS CSIRGNLILF QINTNGFVAV AEPPAEEKYL GKMPSEFKMI
AVLLGDLDNS DGQGKVYFRH DSTPNILGRA ADHIRQGFPD GKVEKPTNTF IVTWENMAAQ
GTPGRGDQLD TKRITFQLVV AYTASSAWAI LLYPRNGLQF LYTSIGGERK LLESCFNEGL
VGWFWQKQGL YFNLTSDDEA SIRQLTKKTN AAQSGVWVYK IGSSPFFVEI EPGKVTRSPE
NEGPHFVESD TIAPAPTSTG TIQRIHPTEQ HEPETRYITS ETLQPTHTTA APTPPRSAPQ
HPQIVVVDED LDVNVFAYNP ETCAHNRHKC SASADCRDHS RGYCCHCRPG YYGNGKDCVA
EGKPQRMNGK VNGQVFVGNL PSPVRLSNND LHSYVVANDG RAYVAISNIP DSVGPSLQLL
SSLGGVIGWA FALEQPGYEN GFSLIGGVFS RQAEVVFQPG NERLTIKQEF KGIDEHDHLV
MSTDLDGRLP AVPLGSTVQI EPYKEIYQYN RNFIISSSSR NYTITSPDGD VQTRSYQWRQ
TIVFQTCPYD EAGWAGATLT TQQLSVDQIF VMFDANNHLI RYAMSNKIGP IRSISTCVTD
AQVRLMLKVS LIVRDSHSEA CCYSEECSET RIQYLGQIHQ NMFLSGPAEE NRPVDHCQRG
SHDCDAPQRA LCRYTGGSAY ICSCLPGFEG DGRVCRDVDE CQQQDRCHAE ASCSNTQGSF
TCQCRPGFHG DGLHCSPTFS EREKTQCEQQ RESAVADSDV PFSFRPRPVG RYVPRCDEHG
AYEPTQCHQS IGQCWCVDAN GQEIANTRTG PHSSPPLFTP APIGPTPRPD VQPIAPGAYL
LFAQSGKIEH VPLDGYIMKK EEAKPLLHVP DRVVIAVAYD CVEKMVYWTD ITGPAISKAS
LTGGDVVPVV TKELQSPEGI AIDHVARLLF WTDSTRDTIE VSKLDGSHRR VLFDTDLVNP
RPIVTNPAYG RLYWADWNRD GPKIEMSNMD GTERVVLVKD NLALPNGLTF DYENQQLCWA
DAGTRNVECM DPHRQLRRNI VEGIQYPFGL VSFGRNLYYT DWRREAVVAV DRHLGKETEE
FLPQKRSRLY GITTTATQCP QVYNYCADNG GCSHLCLPRL GGLSCRCPDT TDGQCEEKVL
//
