ID   A0A3Q4GW33_NEOBR        Unreviewed;       260 AA.
AC   A0A3Q4GW33;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Ribonuclease ZC3H12A-like {ECO:0000313|Ensembl:ENSNBRP00000014195.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000014195.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000014195.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the ZC3H12 family.
CC       {ECO:0000256|ARBA:ARBA00010922}.
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DR   AlphaFoldDB; A0A3Q4GW33; -.
DR   Ensembl; ENSNBRT00000014581.1; ENSNBRP00000014195.1; ENSNBRG00000010961.1.
DR   GeneTree; ENSGT00940000155107; -.
DR   OMA; GTKPEWK; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000010961; Expressed in zone of skin and 1 other cell type or tissue.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.11980; -; 1.
DR   InterPro; IPR040546; Rege-1_UBA-like.
DR   InterPro; IPR021869; RNase_Zc3h12_NYN.
DR   PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR   PANTHER; PTHR12876:SF11; RIBONUCLEASE ZC3H12D-RELATED; 1.
DR   Pfam; PF11977; RNase_Zc3h12a; 1.
DR   Pfam; PF18039; UBA_6; 1.
PE   3: Inferred from homology;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          43..82
FT                   /note="Rege-1 UBA-like"
FT                   /evidence="ECO:0000259|Pfam:PF18039"
FT   DOMAIN          123..260
FT                   /note="RNase NYN"
FT                   /evidence="ECO:0000259|Pfam:PF11977"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          88..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   260 AA;  29911 MW;  11A0BA2166010FBF CRC64;
     DRGFLSQHDV SEAFEAKSRI PQPDGPERAK EEERSHSDSL ATMDAKVERF LKLGYSYSDI
     LRVLESLRHD AQTNDILEEL IKTCHTRTHN NRSVPNSPKL VPRGCSPSQA RPGPDREAAA
     GFRPVVIDGS NVAMSHGNKK VFSCQGLQLA VNWFWDKGMR DITVFVPLWR KEQPKPEAPI
     TDQHILHELE RRKILVYTPS RCVNGKRVVC YDDRYIVKLA FDSDGIIVSN DNYRDLQTEN
     LQWKKFIEER LLMYTFANDK
//