ID A0A3Q4GWY7_NEOBR Unreviewed; 776 AA.
AC A0A3Q4GWY7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Rho guanine nucleotide exchange factor 2-like {ECO:0000313|Ensembl:ENSNBRP00000011818.1};
GN Name=ARHGEF2 {ECO:0000313|Ensembl:ENSNBRP00000011818.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000011818.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000011818.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; A0A3Q4GWY7; -.
DR STRING; 32507.ENSNBRP00000011818; -.
DR Ensembl; ENSNBRT00000012151.1; ENSNBRP00000011818.1; ENSNBRG00000009107.1.
DR GeneTree; ENSGT00940000158341; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000009107; Expressed in mesonephros and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR PANTHER; PTHR13944:SF20; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 228..425
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 465..566
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 650..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..726
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 776 AA; 87457 MW; 7388A74708AEB682 CRC64;
MLPSLTTWRL SDRKLRIQLQ RELLTVSSVC QNKEKERLKE REKEAREREA RSSNGHLFTS
LTVSSTTLCS SCNRSITAKE ALSCPGKHTC TEETLFIPLT CNVAMRSKTP MMKERPSSAI
YPSDSLRQSL LGSRRVRSGL SLAKSVSTNN IAGVTEDSAG LKRILSQSTE SLNFRSRTLS
MESLTDDGLL WSPLLDELQK EGSCVQADSW SLAVEPNFLQ TLHKDLIKQQ DVIYELIQTE
FHHVRTLRIM EGVYRRGMLE EVMLEAGVVH TIFPCLDQLL ELHSHFLSEL FNRRKAGLVE
GSSTNFTVRK LGDLLVRQFS GQTADDWKKV YSEFCSRHPK AVKLYKEVLA RDRRLQQFIR
RATRGPLLRR HGVQECILLV TQRITKYPVL IQRILDNTKG CEEEAQALSR ALGLLKELIS
SVDKEVLELD RSRRLQEIHA RLDPRAQAEV RGGGVFRGGE LLRRRLLHEG TLLCKVQGTR
MKDVQVLLMS DILVFLQEKD QKFTFVVSLD KSPVVSLTNL IVRDIANQER GMYLISDSTP
PEMYELHASS KEDRKTWMSR IQQLPTLTET LTISLTMFSV SVDRLTELLS DASIQKSSIT
NGNQEISGES PLSSLQDVHQ RLISLSTQLH ALQAAVIRQD SMLALLVSAG STPSTTPGSA
PGPRLSRSLS RDTGLEASGE AVLLRRQVEL LQEEVTRLRL RGEDQNWEGV EPGTRRRSKN
GEKSDVMKGE QVSWLRPLAP LATEDPVDQL DGVQEGNEEE EEEVMKISPR SDSPRG
//