ID   A0A3Q4GX14_NEOBR        Unreviewed;       336 AA.
AC   A0A3Q4GX14;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Ion channel TACAN {ECO:0000256|ARBA:ARBA00039635};
DE   AltName: Full=Transmembrane protein 120A {ECO:0000256|ARBA:ARBA00041456};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000013786.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000013786.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Nucleus inner membrane
CC       {ECO:0000256|ARBA:ARBA00004473}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004473}.
CC   -!- SIMILARITY: Belongs to the TMEM120 family.
CC       {ECO:0000256|ARBA:ARBA00009700}.
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DR   AlphaFoldDB; A0A3Q4GX14; -.
DR   STRING; 32507.ENSNBRP00000013786; -.
DR   Ensembl; ENSNBRT00000014163.1; ENSNBRP00000013786.1; ENSNBRG00000010647.1.
DR   GeneTree; ENSGT00390000007848; -.
DR   OMA; AEWQVLI; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000010647; Expressed in mesonephros and 7 other cell types or tissues.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR012926; TACAN/TMEM120B.
DR   PANTHER; PTHR21433:SF1; ION CHANNEL TACAN; 1.
DR   PANTHER; PTHR21433; TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA; 1.
DR   Pfam; PF07851; TMPIT; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        129..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        156..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        186..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        260..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        298..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   336 AA;  40208 MW;  14038B2EB74693F7 CRC64;
     MLFSPGGLSE CLNEWEDLEK DYQQIQDTHR LYKQKLEDVT KLQDSCSNAI ARQRKKLKEL
     TVSLEDPEEK DAIAEIEDSI KDRAHTFFEM EAFLPKRNGL YLNLVLGNVN VTLLNKQSKF
     AYKDEYEKFK LVLTVILFVF SFTCRFLLSY RVLDALFNFL LVWYYCTLTI RESILISNGS
     RIKGWWVFHH YVSTFLSGVM LTWPEGALYQ MFRNQFLSYC LYQSFIQFLQ YYYQSGCLYR
     LRALGERHNM DLTVEGFQSW MWRGLTFLLP FLFFYHFWQL YNSITLFRMF QLPECKEWQV
     FMCGCSYLVL FMGNVFTTLA VVYQKYMNNQ DKSKNV
//