ID A0A3Q4GX60_NEOBR Unreviewed; 1326 AA.
AC A0A3Q4GX60;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Polycystic kidney disease 1 like 2a {ECO:0000313|Ensembl:ENSNBRP00000014600.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000014600.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000014600.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR Ensembl; ENSNBRT00000014994.1; ENSNBRP00000014600.1; ENSNBRG00000011182.1.
DR GeneTree; ENSGT00940000164905; -.
DR Proteomes; UP000261580; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd22831; Gal_Rha_Lectin_PKD1L2; 1.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF195; POLYCYSTIC KIDNEY DISEASE 1 LIKE 2A-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 743..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 836..857
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1078..1098
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1118..1139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1166..1186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1206..1230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1264..1293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..130
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 132..217
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 401..518
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 631..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 930..943
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 1326 AA; 150875 MW; F24C5178E49306BB CRC64;
QSCPEYQEGF DGSCYEFVDL QRSFQDAEEW CERGGGHLAF ILNDETQQFL QKHLKPDRNW
WLGVAPAAPN LTLDSAATEV LAWLDSSDVS YSNWVNLPDD QAACAHVLRH SGFQWEATEN
CSQEFNFICQ FATLQCGSGQ VIEIDDSFYG RKTIHYCRSQ LTPSSTSSKE ECSWIDVTDY
VTHCHGLQAC QAGVDLSAFG EPCPALGSYL SAEYRCKNIT GTVGSVSLTR VNGDVIPVEN
LPEEIEEKFT WVLSPKDRTD DVGVHYLVIK PIVEPGIKSI NASVTVISIA AQCKYWNETG
SFWSEDGCRV GPLTTPLVTQ CLCNHLTFFG SSFFVMPNLV DVSRTAELFA TFTNNPVVVC
FVGAIFCAYL LVVVWARRKD MQDSVKVKIT VLEDNDPLAQ YRYLLSINTG HRHGASTSSQ
VTITLLGTEG ESEPHHLTDL EKPVFERGGG DMFLLTTHFS LGELQSIRLW HDNSGDHPAR
YVSKVMVQDL ETGQKWHFLC NSWLAVDMEE CTLDKVFPVA TEVDLKRFNL FFMKTAKDFR
DGHIWFSVIS RPPCSTFTRV QRVSCCFSLL LCTMLTSIMF WGIPTDPSEQ TMDLHIEFTW
QQVMIGVQSS IIMFPINLLI VSIFRNTRPR EKTTKADAKQ GKTVRVSPSQ TSSPQKEIKD
ITPDTVMKLY RQLQLIEKEL GMLGPSQFPN PDSYNRAMQQ VQGMKGLLEY HLPMSILDGD
SCFPGPEESL GGKKKCCQGG LPWWFVFIGW ILVIATSGVS GYFTMMYGLT YGKDRSISWL
ISMVVSFFES LFITQPLKNP DAVQAARRDS TCSFYKPPPP TDIEKMRNNM IKEQKVFALI
REIVYTGFMW MLLLVAYGQR DPNGYFLTQH IRKSFSKGVS DTMSIQDVFN WANTTLLSNL
FGEYPFITDG NSRLVGNARL RQVRVQKNSC HIARSMQESI PDCHTPYSWE LEDMGSYGPG
WTQPVGRNAS TNIHDPWKYK SQRKLRAYPI WGNVKLYRGG GFVMDLGPDF QNSSILQYLY
ENTWFDVYTQ AIFVEFTVYN ANVNLFCIVT LMLETTATAF QFRSELQTVR LYQSTGGLHI
FVMASEIIYF LFIIYYMFVQ GKLMKKQKWT YLKNKWNLLE LAIIILSWSA LCVFIKRTLL
GNRDMNYYQN NKEFVSFHET AKADAVLGYL IAFLVLLATV KLWHLLRLNP KLHMITATLQ
RAWTDISGFL VVMTIMFLAY SIASNLMYGW KLYSYRTLLD AVQTMVSLQL GIFNYEEVLN
YNPVLGAFLI GSCIVFMTFV VLNLFISVIL VAFTQEQIHH KPSEEDEIVD LMLMKICSLF
GIKCKK
//
