ID A0A3Q4GZD2_NEOBR Unreviewed; 2315 AA.
AC A0A3Q4GZD2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Translational activator GCN1-like {ECO:0000313|Ensembl:ENSNBRP00000014641.1};
GN Name=GCN1 {ECO:0000313|Ensembl:ENSNBRP00000014641.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000014641.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000014641.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GCN1 family.
CC {ECO:0000256|ARBA:ARBA00007366}.
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DR STRING; 32507.ENSNBRP00000014641; -.
DR Ensembl; ENSNBRT00000015036.1; ENSNBRP00000014641.1; ENSNBRG00000011227.1.
DR GeneTree; ENSGT00940000153612; -.
DR OMA; KYATQRG; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000011227; Expressed in muscle tissue and 9 other cell types or tissues.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 7.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR004155; PBS_lyase_HEAT.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR23346:SF7; EIF-2-ALPHA KINASE ACTIVATOR GCN1; 1.
DR PANTHER; PTHR23346; TRANSLATIONAL ACTIVATOR GCN1-RELATED; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR SMART; SM00567; EZ_HEAT; 3.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; ARM repeat; 4.
DR PROSITE; PS50077; HEAT_REPEAT; 4.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..2315
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018564296"
FT DOMAIN 1007..1240
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1258..1296
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1300..1338
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1420..1456
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1648..1685
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1899..2125
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT COILED 454..495
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2315 AA; 253941 MW; AB05D6B2DC99D9D5 CRC64;
LPGSAAFVGL SWTCLLVSSV FSAPEKREGP TWKKMVEVQS LLVAEVVGGA KATAKKSSLK
NLSHLWKGNP GMVNQYISTL LTLEQSPTTL ALLGVCFDFC SAQKDNATIE KHKSALLDLY
VKSVLMSKTK PQQHILDKSA SLLRHVSHPE FKETLLPTLQ KTMLRSPENA MQSELPLAFG
HTLLTVLQLC ERLFLDHAHR LNSSKTQMYH QATVAALLSR SWRVRKRAQQ TIRKLLSSLG
GSSLAHGLLG ELRVVINKHK VLPQDSVVSE SGELTELGRS YVPPRVLLDA LCVVCSSASQ
WGDPAEAESL AMETLIVSHH PSIVEARRGL WPVLLSSMNL KAEEFIENNL EAILPQLLKV
DADNQAVRNA VGSLSRLSPN KLLPRVISHI TEGLSKPALL QVTREEYAIM LTPEGELYDK
SIIQSAQKEN TKKVNMKREN KAYSYKEQII ELELQEELKK KKGIKEEIQL TTKQKEMMQI
QLEKESATRK RLQELDGELQ SVVGLLEATL IERPAQITRE LPAVLQVLMP LLHSPLAAPS
IQQVFLDIGV CLMPKSLQHL AVLVGHVTLR LLKPECDLDK AWEQEDLATA AHRTVMLLHN
HTVPQREGKT ADAAPLSAPA FSFCFPLLNA TLRESSDSTE ETENTMMRAL QVINEHSQLR
ADTDNDDVAI DENGPELLPR VSMLLLLTRV ISTAAPRLQV LASQCLTALC ASAGGEEGCT
VAEQPEIDVL LNALLSPCFS VRDAALRGLL EMEFALPTDC TDASGMSLLR RLWVARFDVE
EEGQALAEKL WESLGLELVP EICSLLIGDV THHEEAIRSA AADALSSAVS QYRDQSATVL
CQLTELYHQK LYRPPPVLDA LGRVISEAPP DQWEARCGIA LALNKLSQYL DESQVTPLFL
FFVPDALNDR HTDVRRCMLD AALSALNTHG KDNVSSLLPV FEEFLKNAPQ DASYDSVRQS
VVILMGSLAK HLDKNDPKVK PIVAKLITAL STPSQQVQES VASCLPPLVP AIKEDAAGIV
KNLLQLLLES DKYAERKGAA YGLAGLVKGL GILALKQQDI MTTLTEAIQD KKNFRRREGA
LFAFEMLCNM LGKLFEPYVV HVLPHLLLCF GDGNQYVREA ADDCAKAVMR NLSAHGVKLV
LPSLLVALEE ESWRTKAGSV ELLGAMAYCA PKQLSSCLPS IVPKLTEVLT DSHVKVQKAG
QQALRQIGSV IRNPEILAIT PILLDALTDP SRKTQTCLQT LLDTKFVHFI DAPSLALIMP
IVQRAFQDRS TDTRKMAAQI IGNMYSLTDQ KDLSPYLPSV IPGLKASLLD PVPEVRTVSA
KALGAMVKGM GESCFDDLLP WLMETLASEQ SSVDRSGAAQ GLAEVMAGLG VEKLDKLMPD
VVQTASKVDI ASHVRDGYIM MFIYLPLTFG DKFTPYVGPI IPCILKALAD ENEYVRDTAL
RAGQRIISMY AETAIALLLP ELEQGLFDDL WRIRFSSVQL LGDLLFHISG VTGKMTTETA
SEDDNFGTAA SNKAIISALG AERRNRVLSG LYMGRSDTQL VVRQASLHVW KIVVSNTPRT
LREILPTLFT LLLGFLASTC PDKRTIAART LGDLVRKLGE KILPEIIPIL EEGLRSDKSD
ERQGVCIGLS EIMKSTSKDA VLVFSESLVP TVRKALCDPL EEVREAAAKT FEQLHATIGH
QALDDILPTL LKQLDDEETA EFALDGLKQV MAVKSRSVLP YLVPKLTAPP VNTRVLAFLS
AVAGDALTRH LGVILPALLS SLKGKLGTED EAQELCSCQT VILSVEDEVG QRIIIEDLLE
ATRGTDPGLR QAAVTILNAY FARTRLDYSA HTRTLLSGLI RLLNDSNPEV LSQSWDTINS
ITKKLDASSQ LALIDDLHRD IRSVAGDVKG QHLPGFCLPK KGVTCILPVL REGVLTGTPE
QKEEAAKALG GVIKLTSPEA LRPSVVNITG PLIRILGDRF AWTVKTALLE TLTLWSKFLS
EALKPFLPQL QTTFLKALQD SSRAVRLRAA EALGQLVSIH TKVDPLFTEQ LSAIRNAEDS
GVRETMLQAL RFVIQGAGSK VDPAIRKNIT TTLLGMLGHD EDATRMASAG CVGEMCAFLS
EEELKSVLLQ HVLADVSGVD WMVRHGRSLA MAIAVKSAPG KLCGNEYCDT VRETILANAT
ADRIPIATSG IRAMGYLMKH HLRTEGSSGV SQQMITQFVK CLQNQSSDVR LVSERVLWWV
FKEPSLPSVD VNLIKPLLKT LLDNTKDKNT SVRAQSEHTI VNLLRLRQGE ETMQTITAIL
DSASNDLLSE CHRRSLKKIA SQPDSNEEID DTILT
//
