ID A0A3Q4GZY2_NEOBR Unreviewed; 1770 AA.
AC A0A3Q4GZY2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Plexin A3-like {ECO:0000313|Ensembl:ENSNBRP00000013068.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000013068.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000013068.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 32507.ENSNBRP00000013068; -.
DR Ensembl; ENSNBRT00000013437.1; ENSNBRP00000013068.1; ENSNBRG00000010108.1.
DR GeneTree; ENSGT01050000244850; -.
DR OMA; CTHRLAP; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000010108; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF32; PLEXIN-A3; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 2.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR Pfam; PF18020; TIG_2; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 2.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1770
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018625014"
FT TRANSMEM 1145..1171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..506
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT COILED 1175..1217
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1770 AA; 199479 MW; AF746D6214C00581 CRC64;
MVFSCSSPLL LLPLLSLVLF SSPILSAPAA PPPPSVPSGR VVYRAFDTSL THLTVHQSTG
EVYVGAVNRV LKLSANLTEL RSHMTGPVED NASCYPPPSV RSCAHRLEMS DNVNKLLLVD
YIGNRLVACG SIWQGVCQFL RLEDLFKLGE PHHRKEHYLS GAREADGMAG VIVEDHCHLF
IGAAIDGKSE YFPTLSSRKL VVDEESVDMF SLVYQDEFVS SQIKIPSDTL SLYPAFDIYY
VYGFSSRTYV YFLTLQLDTQ LTQMDAGGEN FFTSKIVRMC SDDTEFYSYV EFPLGCTKDG
IEYRLVQAAY KQKPGRRLAQ ALGLSENDDI LFVVFSQGQK NRSNPPRETV LCLFTLHDIN
LAMRERIRSC YRGEGRLSLP WLLNKELPCI HTPKQIGDDF CGLVLTQPLG GLRVIEGQPL
YEDRTEGMGA VAAYTYGEHT VVFVGTRSGQ LKKIRVDGIP PPAENALLYE TVTVVEGKPI
LRDMVFSPDH QYIYLLSDRQ VNTPAELLHD QSEKRSRDSS PFVCPFYFFF EFYSPKHTNP
QTAEKQVYTH PLILNLFLLP SRFSLLSHLM FCNHVSFSVT RPYIDHYELS IKKDVVMLLI
SGAKRVVQLS LRSTETGHQF ITTNLIYYNC SVLNSCTSCV SSEFPCHWCK YRHICTNNLQ
DCSFQEGRVS NMEGCPQIIP TSDILVPAGM VRPITLRARN LPQPQSGQKN YECVFNIQGK
VQRIPAVRFN SSCIQCQNTS YWYEGDEAGD LPVDFSIVWD GDFFIDKPAS MKALLYKCEA
QRSSCGQCLK APTAFECGWC TESRKCLLRQ HCPSPEQNWM HYTRHNLRCS HPRITKVGNQ
TCDLHAAGCV VEQGLCTILH NRDSPTFSRV HPEKGPVSGG TRLTVMGRHL NAGSSVTVYI
NKEECLFVKR TDREIVCITP SSTSGTGEAP IRLKIDRAEV TSTDTKYTYT DDPTITSIEP
NWTILNGSTL ITVTGTNLHT IQEPKVRAKY GGVETNNYCT VVNDSTMTCL APGLVYTKPD
PPEGALRPDE FGFIFDQVSS LLVLNSTPFT HYPNPTFDSL GNSGILEVKP GSPIILKGKN
LIPPAPGNNR LNYTVLIGES PCLLTVSENQ LLCDSPDITG EKRVILVGGL EYSPGMLHIY
SDSALTLPAI IGIGAGGGVL LIAIIAVLIA YKRKTRDADR TLKRLQLQMD NLESRVALEC
KEAFAELQTD IQELTNDMDG VKIPFLEYRT YTMRVMFPGI EEHPVLKELD VCTIRQDVRI
FESLDPQLQF FPDHNNRPPC LSSFNPQIPA SCSLTDLIKL FLSNLMTESV AEKMLTNWFT
FLLHRFLKEC AGEPLFMLYC AIKQQMEKGP IDAITGEARY SLSEDKLIRQ QIDYKQLTLM
CIPPEGEVGT EVPVKVLNCD TVTQVKDKLL DAVYKGIPYS QRPQADDMDL EWRQGRLTRI
ILQDEDVTTK IESDWKRLNT LAHYQVTDGS VVALVQKQVS AYNIANSFTF TRSLSRYESL
LRTSSSPDSL RSRAPMITPD QETGTKLWHL VKNHEHSDQR EGDRGSKMVS EIYLTRLLAT
KGTLQKFVDD LFETVFSTAH RGSALPLAIK YMFDFLDEQA DKRQITDPDV RHTWKSNCLP
LRFWVNVIKN PQFVFDIHKS SITDACLSVV AQTFMDSCST SEHRLGKDSP SNKLLYAKDI
PNYKSWVERY YRDIAKMPSI SDQDMDAYLV EQSRLHGNEF NTLSALSELY FYINKYKEEI
LTALDRDGYC RKHKLRHKLE QAINLMSGSS
//
