ID A0A3Q4H0A5_NEOBR Unreviewed; 900 AA.
AC A0A3Q4H0A5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Probable ribonuclease ZC3H12C-like {ECO:0000313|Ensembl:ENSNBRP00000015760.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000015760.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000015760.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the ZC3H12 family.
CC {ECO:0000256|ARBA:ARBA00010922}.
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DR AlphaFoldDB; A0A3Q4H0A5; -.
DR STRING; 32507.ENSNBRP00000015760; -.
DR Ensembl; ENSNBRT00000016185.1; ENSNBRP00000015760.1; ENSNBRG00000012175.1.
DR GeneTree; ENSGT00940000155107; -.
DR OMA; YHRCESP; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000012175; Expressed in skeletal muscle tissue.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd18729; PIN_Zc3h12-like; 1.
DR Gene3D; 3.40.50.11980; -; 1.
DR InterPro; IPR040546; Rege-1_UBA-like.
DR InterPro; IPR040757; Regnase_1/ZC3H12_C.
DR InterPro; IPR021869; RNase_Zc3h12_NYN.
DR PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR PANTHER; PTHR12876:SF36; RIBONUCLEASE ZC3H12C-RELATED; 1.
DR Pfam; PF18561; Regnase_1_C; 1.
DR Pfam; PF11977; RNase_Zc3h12a; 1.
DR Pfam; PF18039; UBA_6; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 139..178
FT /note="Rege-1 UBA-like"
FT /evidence="ECO:0000259|Pfam:PF18039"
FT DOMAIN 225..380
FT /note="RNase NYN"
FT /evidence="ECO:0000259|Pfam:PF11977"
FT DOMAIN 850..895
FT /note="Endoribonuclease Regnase 1/ZC3H12 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18561"
FT REGION 57..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..636
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 900 AA; 99427 MW; C83974FBBB045190 CRC64;
MGLKDHLEDG TGHILSPGLD LDYLHVEGAE RQAGNLGAGV TVKSSNTAGS RGISSIIHSS
SSSSCSNFSE ESAISDSEDE RLQTGSGSDS KTPHHDQLHL HQREESSVFQ PVRLDLAPNT
SPGDPPETSL TDPITHCRTK VEFALKLGYP EELVLLVLRK LGPDALINDI LGELVKLGTK
IEMDQQGGQA VSQSPSSSLS STSNSSLDSS RLLCPSHLLQ DKENLRPVVV DGSNVAMSHG
NKEVFSCQGI KLAVDWFLER GHRDITVFVP AWRKEQSRPD ALITDQEILR RLEKEKILVF
TPSRRVQGRR VVCYDDRFIV KLAYESDGII VSNDNYRDLA NEKPEWRKFI DERLLMYSFV
NDKFMPPDDP LGRHGPSLEN FLRKRPVIPE HRKQPCPYGN KKMFSYFYHP ERGSQPQRAV
ADELRASAKI SSVASRGLLE HALMAKSQKN GQSEGMAEAL LIRDTGKKQP NRSLQSSFSE
LSEDKTQVSS KVEEQRRNSS LSGSCSNNIV GHPAPGGPPS LGHLERWEHP AGSTGCSSGI
AGASGPNKAE SYYRCSSPVV GYNSVVKAYS GLSLVVPQTP ECFFPGELGT SSLASDCSSE
SSVSSDSFSP DPVLDDSPKC HHHHPHHHHH HHYSGQYPHQ ASRVSPSLSQ HSPRGYVHPQ
GLWRQRDFGI EDTPASVASR ISPHRVNTAS VYIQPQKQLQ LLANFPGEPP HPQHPPQTPT
AHARSQSFPL GHNMVGSLWP EHGLQDRVCE GSPVHSRRNY SVRTQQPQHQ QNWDPNYEPP
PKPYYDLFSY KSFPQVHGHS PWGQQVHSSP HGLLIPGLPS LSQQSLPSVP THKSHMPSAT
QHAKPTALGR YQDLRERVFV NLCGIFPPDL VRMVMTRNPH VTDAQELAAA ILMEKSQHSS
//
