ID A0A3Q4H0D2_NEOBR Unreviewed; 941 AA.
AC A0A3Q4H0D2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A5 {ECO:0000313|Ensembl:ENSNBRP00000015036.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000015036.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000015036.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; A0A3Q4H0D2; -.
DR STRING; 32507.ENSNBRP00000015036; -.
DR Ensembl; ENSNBRT00000015449.1; ENSNBRP00000015036.1; ENSNBRG00000011611.1.
DR GeneTree; ENSGT00940000157488; -.
DR OMA; RETEGNC; -.
DR Proteomes; UP000261580; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF20; ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 376..398
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 410..441
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 461..483
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 580..598
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 666..685
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 706..730
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 766..785
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 792..811
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 843..874
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 69..298
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 348..844
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 148..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..931
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 941 AA; 106149 MW; F4AC0DBA06770FCF CRC64;
VNSDKSKHAA VVNNLTSLSP AAERLRYILS EDDDMPTPTL FTEMDTLQRE GEELEWKESA
RWVKFEEKVE EGGERWSKPH VSTLSLHSLF ELRTCLQTGT VLLDLDGYSL PQIVERQIEE
GMISPDLREK ISFVLLRKHR HQTKKPIHRS FADIGKSSSS TSHAQSRSMN DIADTPSTDQ
LKNKFMKKIP RDAEASNVLV GEVDFLNKPF VAFVRLAQAT TLGGLTEVPV PTRFLFILLG
PQGKAKSYNE IGRAIATLMV DDLFSDVAYK ARDREDLIAG IDEFLDEVIV LPPGEWDPKI
RIEPPKKVPS AEKRKSVFSL NELGQMNGTA GGGGGLAEDE EMPVQHEFCG GLYLDIKRKL
PWFPSDFYEG FHIQSISAVL FIYLGCITNA ITFGGLLGDA TDNYQGVMES FLGTALAGSV
FCFFGGQPLI ILSSTGPILI FEKLLFEFSK SNSIDYMELR LWIGMHSCLQ CFILVATDAS
YIIKYMTRFT EEGFSSLISF IFISDAIKKM VGAFKYYPIN TDFKPDYVTT YKCESPMPDN
SSSVSGLNVT ALDWSQLSKK ECVKYGGSLV GKSCKFVPDL ALMSFILFFG TYSMTVSLKK
FKFSRYFPTK VGKLSVYICV LLNQVTQCFC KTHNELFHHS GLKTSIKTPT RPGRGWLVMP
FGKNPWWVYL ASFVPALLVT ILIFMDQQIS AVIVNRKENK LKKGCGYHLD LFWVGVLMAT
CSFLGLPWYV AATVISIAHI DSLKMESESS APGEQPQFLG VREQRVTGIL VFVLTGVSIF
LAPVLKFIPM PVLYGVFLYM GVASLSGIQF WDRIKLYMMP SKHQPDYTYL RHVPLRRVHL
FTLIQIICLA VLWVLKSTFL AIIFPVMILG LMVVRKMLDM VFSQHDLAWL DDLLPEKEKK
KKDDDKKKGK EKEKEKEKKK PKPDDSEEEV RNSSFCCPLQ D
//
