ID   A0A3Q4H1X4_NEOBR        Unreviewed;       912 AA.
AC   A0A3Q4H1X4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Inter-alpha-trypsin inhibitor heavy chain H2-like {ECO:0000313|Ensembl:ENSNBRP00000016460.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000016460.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000016460.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the ITIH family.
CC       {ECO:0000256|ARBA:ARBA00010158}.
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DR   AlphaFoldDB; A0A3Q4H1X4; -.
DR   STRING; 32507.ENSNBRP00000016460; -.
DR   Ensembl; ENSNBRT00000016901.1; ENSNBRP00000016460.1; ENSNBRG00000012689.1.
DR   GeneTree; ENSGT00940000157945; -.
DR   OMA; AKQMWAY; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000012689; Expressed in liver and 3 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF14; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2; 1.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..912
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018618784"
FT   DOMAIN          46..175
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          300..483
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   912 AA;  101967 MW;  C8A53A92B7589434 CRC64;
     MRCLQVLLLG LLLLHQGCCF EFVIDGEWED EMVTKHLYEI SKSRSDIPSF SAQAIRGDDI
     TVRSYKVESR ITSRFSHTIV RSSVVNSGST PQSIAFNVQI PKRAFITNFT MNVNGITFVG
     SVKEKTVARN LYAQARARNK AAGIIRTNSQ DMETFKTEVH VPSGSNIEFE LHYQEMMHRK
     LNLYEHTLHL QPGRLVPQLQ VDVYIFEPKG IATVKASNTF GAQFADLIKV TSTKDKAHIV
     FKPTVQQQKQ CENCTESAVE GVITVLYDVN RDSNAGELQV SDGHFVYFFA PSNLSPLPKN
     IVFVIDVSGS MWGVKMKQTV QAMKAILDDL TIDDYFSIVD FNHNVRCWSE ELVPGSSIQI
     ADAKRYIENI KPNGGTNINE ALLRAVQMLV RASNHRVIDP RSVSMIILVS DGDPTVGEIK
     LSAIQKNVKR VMREEFSLFS LGIGFDVDYD FLERIAMENR GMAQRIYANH DAAEQLRAFY
     SQVSSPLLRK ITVQFQADSV AEVTQNHFDK FFSGSELVVA GKVLPSESNT LTSFAIGSAA
     RLDITLETDA DTTELDAELA KQQHSFTGFA RQMWAYLTIK QLIGERSLAT TAVKKRKITQ
     RIMTLAVEHQ FVTPFTALLV ESGDATERLL ADSPKDPKHG CCSVVYQPPP WVHMPTPAPP
     MGELSASLPV DNDPHFIIHL PRSNMDICFN IDSKPGHILN LLSDSGTGVT VNGQLIGSKK
     VNKRTYFGTI GIYHQPDGIS VIVSTDGITM TDGTNNHSFT WGSTAEIRQD GISIVKNSNV
     IITINNSTQV MVLLHRVWKK HPVNVDFLGI YIPNENQYSP LVHGLIGQFS IEPEVILYDI
     HKGADPLKKE ATMEVKGNKL LVTRGWQKDY RRDKKRGSNV YCWFIHNSGK GFIDGHYSQY
     IVPNLSSFLH MP
//