ID A0A3Q4H2H9_NEOBR Unreviewed; 1066 AA.
AC A0A3Q4H2H9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Integrin alpha-M-like {ECO:0000313|Ensembl:ENSNBRP00000016685.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000016685.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000016685.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q4H2H9; -.
DR STRING; 32507.ENSNBRP00000016685; -.
DR Ensembl; ENSNBRT00000017135.1; ENSNBRP00000016685.1; ENSNBRG00000012848.1.
DR GeneTree; ENSGT00940000154838; -.
DR OMA; CQRIKCD; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000012848; Expressed in mesonephros.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR048633; ITGAX-like_Ig_3.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF84; INTEGRIN ALPHA-L; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF21520; ITGAX-like_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 112..289
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 398..458
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 462..520
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 524..585
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1066 AA; 118181 MW; D327586E9830448D CRC64;
MFSAAGFGYQ VVQRQSDLLV SAPLEQYSQN GRGRIYRCTT TSQNCQNIQL QGTKSSILKW
HNFVSSQACG PSIPKDCRSI TMYNGVCFQL DHSNRFGSPI PSSLQECPSQ VDIAFLLDGS
GSVSTFDFQT MKKFVKNLIQ SFFTFSISQF STSPQVHFYF KEFFSSGSVK VDIDGIRQLG
GYTYTAKAIR HVVNIVFTPQ RLSRQNVKKV LIVITDGESN DRHDLGNAAQ LAENKNIVRF
VIGVGNAFTK SEAKKELHTI ASSPSSKHVF QVENFNALEI IRQTLQEKIF SIEGSQTSGA
TLKMEMSQEG FSAVYVPGGI QMSIVGANQW KGGYVQYTTE GQKVKTYEDV SLEPDSYLGY
SMAVAKTQSG SLTIVGAPRY KHRGVVVAVN RQTFKNQKIE PFSSQYQTGE YFGAEVCTMD
INNDDITDLI FISAPMYTEP DREGRVYICR LTGLFVECNF DDPLVLRGRA AVKGRFGSSL
AVLPDLNSDG FRDLAVGAPL ENNGEGSIYI FHSEGGRISP TYSQRITGSE VQSGLKFFGL
SISQSSFDHS GDRLPDLAVG SKGKVVLLRS RPIVMIEPEV SFSPNQIPTH NVNCSKPLEN
TATVCFTMSR LSTVNTAEAR INYTLTVDTT RKPPNNRAYV SRKQQEQSGS VIVDLTKKKC
STVKFLIETC PEDALNALSN ELKFMLDGLP SNTNLRPSLA PQAQTTTIYP LEFEINCGTD
NKCVDKLKVD FGFTRSPEVK VGIDELLDVT VTVENRGENS YNSRVILTYP AGLSYRKFTI
QQGRIECNSL DSEDGLSRGR TDCTIDKPIF KSKTKASFIV SYGIDTTNQL ERKIFVTANA
TSGNQEHAPT SELYIKKWID VKYSIFMTFE SSLSYNNFTF GTNNLQKPVQ QSIKVTNDIR
ALHFSVAIRV PVKLGEKDIW VDLSSLQISD CQSENDEAPS VKDFVPKIQK DKVVDCSVAM
CRVFKCSTFM GRLQSRTYEI SANLSSGWIE QIGLQSAKFL LTSTVSLEYD KNQYIYLSTG
SKNNPPVRKF QSIFQFQSAG TVLASGGALG GRGFRPPCIC IHYIGH
//