ID A0A3Q4H3Z6_NEOBR Unreviewed; 338 AA.
AC A0A3Q4H3Z6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Erlin-1 {ECO:0000256|ARBA:ARBA00040567};
DE AltName: Full=Endoplasmic reticulum lipid raft-associated protein 1 {ECO:0000256|ARBA:ARBA00041391};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000014623.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000014623.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family.
CC {ECO:0000256|ARBA:ARBA00008164}.
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DR RefSeq; XP_006800766.1; XM_006800703.1.
DR RefSeq; XP_006800767.1; XM_006800704.1.
DR AlphaFoldDB; A0A3Q4H3Z6; -.
DR STRING; 32507.ENSNBRP00000014623; -.
DR Ensembl; ENSNBRT00000015018.1; ENSNBRP00000014623.1; ENSNBRG00000011288.1.
DR GeneID; 102796386; -.
DR CTD; 10613; -.
DR GeneTree; ENSGT00390000014666; -.
DR OMA; YTAHKHA; -.
DR OrthoDB; 3129813at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000011288; Expressed in liver and 7 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR CDD; cd03406; SPFH_like_u3; 1.
DR Gene3D; 3.30.479.30; Band 7 domain; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR033294; Erlin1/2.
DR PANTHER; PTHR15351; ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG; 1.
DR PANTHER; PTHR15351:SF2; ERLIN-1; 1.
DR Pfam; PF01145; Band_7; 1.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; Band 7/SPFH domain; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Signal {ECO:0000256|SAM:SignalP};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..338
FT /note="Erlin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018703629"
FT DOMAIN 23..189
FT /note="Band 7"
FT /evidence="ECO:0000259|SMART:SM00244"
FT REGION 309..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 338 AA; 37929 MW; 14292BAB6688A89D CRC64;
MTMPHVGAVF AAITGVMAIM LHSSIHKIEE GHLAVYYRGG ALLTSPNGPG YHIMLPFITT
YRAVQTTLQT DEIKNVPCGT SGGVMIYFDR IEVVNMLVPS AVVDIVRNYT ADYDKTLIFN
KIHHELNQFC SVHTLQEVYI ELFDIIDENL KTALQKDLNV MAPGLTIQAV RVTKPKIPES
IRRNFELMEA EKTRLLITAQ TQKVVEKEAE TERKKAIIEA QKVAQVAEIQ FQQKVMEKET
EKKISEIEDA AFLAREKAKA DAEFYTAAKF AEANRLKLTP EYLELMKYQA IAANSKIYFG
QDIPNMFVEG GNGPPKSPRS PSLPNAESDF FKVKPDGQ
//