ID A0A3Q4H4B7_NEOBR Unreviewed; 490 AA.
AC A0A3Q4H4B7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=RNA-binding protein FUS-like {ECO:0000313|Ensembl:ENSNBRP00000011202.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000011202.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000011202.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RRM TET family.
CC {ECO:0000256|ARBA:ARBA00008448}.
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DR AlphaFoldDB; A0A3Q4H4B7; -.
DR STRING; 32507.ENSNBRP00000011202; -.
DR Ensembl; ENSNBRT00000011522.1; ENSNBRP00000011202.1; ENSNBRG00000008712.1.
DR GeneTree; ENSGT00940000157290; -.
DR OMA; SYSKGPM; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000008712; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd12535; RRM_FUS_TAF15; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034870; TET_fam.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR23238; RNA BINDING PROTEIN; 1.
DR PANTHER; PTHR23238:SF5; RNA-BINDING PROTEIN FUS; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00641; zf-RanBP; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00322}.
FT DOMAIN 271..356
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 410..440
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT REGION 1..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 49062 MW; 4586F6993B13309D CRC64;
YSQTSSQYGG GGGASQGYGQ SSGPGYGQQG YGGYNQSSDS SSSSYSQGGY SGYGHPQSGY
GSPSSNQGGG GGGGYGHSSQ SYSPGGYNSS NQPSSMSYSQ QSSFSGYSQQ QQPPPPSYEG
NSPAPAYQPP SSGASGGGYG SSGGQPSGNY GGSGSHPQPS QHGGGHYNQP PSYNTPPPPS
YSQQSQYGQD SPPISGGGGG GYGGPDGGYG GQEGRGGRGR GGGGFGGRGG GGYDRGFDRG
GRGGPRGRGG MMGDRGGFNK FGQDQDNSDN NTIFVQGLGD DYTVESVADF FKQIGIIKVN
KKTGLPMINL YTDRETGKLK GEATVSFDDP PSAKAAIEWF DKDFNGNPIK VSFATRRADF
GGRGGMRGGR GRGPMGRGGF GGGRGGGFPG GNGGNGGGGG GASGGGGQQR AGDWKCSNNC
GNLNFSWRNE CNQCKAPKAE DAGGMSPMGG DRRGGFDRGG FRGRGGDRGS GGFRGGRGGE
RGGFGPGKMD
//
