ID A0A3Q4H4E8_NEOBR Unreviewed; 3861 AA.
AC A0A3Q4H4E8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Dystonin {ECO:0000313|Ensembl:ENSNBRP00000017505.1};
GN Name=DST {ECO:0000313|Ensembl:ENSNBRP00000017505.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000017505.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000017505.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 32507.ENSNBRP00000017505; -.
DR Ensembl; ENSNBRT00000017977.1; ENSNBRP00000017505.1; ENSNBRG00000013245.1.
DR GeneTree; ENSGT00940000155008; -.
DR OMA; TMYASAT; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000013245; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 15.
DR Gene3D; 1.20.58.60; -; 23.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169:SF24; DYSTONIN; 1.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF02187; GAS2; 2.
DR Pfam; PF00435; Spectrin; 21.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00150; SPEC; 29.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 24.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 3418..3453
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 3454..3489
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 3494..3611
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 15..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3616..3635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3657..3744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3774..3861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 111..166
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 478..508
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 533..607
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 779..806
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 994..1028
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1279..1313
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2415..2442
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2667..2705
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 3621..3635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3669..3740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3774..3797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3804..3851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3861 AA; 435930 MW; E5AEE962783D4D6F CRC64;
MSVFIGETEG VYRQVGGRVQ ENGNLPEEPS AKGLITDDDN ANGNALQATE KDFGRETSSE
DNKSPNLDKQ YQRLKAHHQE ILSQQQDLIM ATQSAQAMLD KQANVLSPQE KEALQKNIQE
LKERYETSLT QAEQQMKQVQ CVQEELKKFQ DDCEEFENWL NQAEEEILEL GAPASSLNIL
SDNLQRQKSF SEDVISHKGD LRFITISGQK VLDVAKAFGS ADPAAKNPLL HVDTSGTCSA
VKDKLDSAAS RYKTLHSQCN LLGNNLKDVV DKYKKYDDSS TGLLKWLNSS EEEARKQQSE
AIAADPQTLQ KQLEDTKVLQ GQMMGHQTAI DSLRKTAESL ITSEGDLLSN PDEIQETVDD
IVERYDNLSK SVSDRNEKLQ ITLTRSMSVQ DGLDEMMGWM EGVEASVEEK GQITLDSASL
GGILSKEAAL EQDIASRQSS ISAMKAKVKK FVETADPSAA ALLQSKMDSL SQRFSDACDQ
HRQKIATLEK LKEKVEQFEN VAEKVQQFVL KRSQDLHETD GPGKTFNELS QLMQNTKAEM
AEYAGDLEKL QTLSKELSEI SPDGNKAQIQ SKLDNLSNVF STFKDTIKEK EEELSSCQDQ
LGEFRSAASA LTKWLEEANE KVPADQPSSS EKTLESDLQI VTGLLDEWTS KGSAVQDLNT
KGSTLCNLIT FLTSPAKTKT PNKSALTNGD GPASHTYLTN KELMVIQQNM SSINVGYTDL
GETLKNRSAQ LSSLLQKVKE AQKETDDMML WLKDMKKTAQ SWNSAATEKD SVKTQLEQQK
AFEDNMKQKQ EALHKLREKL LDLIKTHPNS PEAAKWKQML AEIDAAWADI SGSVEERKQH
LEQSNKNLDI FQTTEQQLGQ WLSEKELMMS VLGPLSIDPN MLKMQKQQVQ ILQNEFKSRK
PQYEQLEEAA SAILSSSGDQ DPSSGKLVNE QLAAVTQKWA GLTGQLDQRD SLIDQAVVKT
GKFQELLRSL SNTATQLESQ LTNHQGLSTR PDAVKKQLED AQNISAQLRE EKKKLKEAEA
INEELTAMVT EDYLKADLAR QLESVCKPFK QLEEKAAKRI EQLNSTFASS QQFHQTSKDL
QSWLGEKLQD QLKPKPISAK VEVLQQTVEE HSKLQKALGE HEKAFNTIIG EGELLLHNID
GAEKLALQGQ LTTLSSNWEE VKKSSAEQAD KLQTALMRSL KYQEHAEKLN SWIQECEASE
GRVKLTVDPA AVETSISQLK ALQKDVDKHR GLVEQLNAAA DSLLEVANTD TDAIKEEKAS
TGKRVDNIVE SLQGKRESLE KISHTVKEFN DACKEAKTQL EGAKKQVDAY ETQGVQAHSN
KSLTNMKAQH KSLEAVQNQV EHMKALAKDL VVDVPDAEGV TDLLLQADSI EKDYGNLNKK
LEETCQALEG KLQGIGQFQN NIREMFGQFT ELDDELDSMS PVDLNLDTLK EQQDSIQSFV
AKLRELMANT ANAGDSCKKM LESEPSPDLL GLKRDLDALS KQCGKLLDRA KGREVQVQST
LTKLEELYGK LNQMEDKLCR AVDKEVSQEP VSMETEVINQ QLEAFKAFQK EDIDPLQNQL
QDINSLGQGL IQNAAKGTST KKLEDDLEGV NSKWNTLNKK IAERSAQLHE ALLHCGQFQD
ALESLLSWLT DTEELVANQK PPSAEFKVVK AQIQEQKLLQ RLLDDRKPTV ELIKKEGGKV
AELAESVDKE KVAKEIECLG QRWDTLLKKA ENRHKQLESI LVVTQQFHET LEPLSEWLSA
TEKHLANSEP IGTETSKLED QISQHKTLEE EIMNHSKDLF QAVNLGQMLK TVSSVDDKEF
VQSKLDTTQA SYIELQERCR RKAEMLQQAL ANAQLFGEDE VALMNWLNEI HTRLCEVSVE
DYRLEVLEKQ LADQRALQSD IGLRKKNVDQ AISNGVELLK QTTGDEVIVI QGKLDGIKTK
YAEINSMSAS VLKTLEQVLS LSSKLQHTHT DLSSWLEKAE AEINSFAHQD PVGKQLIHSQ
SRQKAMLKEI KDQKPVLDQL NELSSSLLDL IPWHTRESLD KLVSEDNERY RAAYDTLTQK
VDQINADILK SQQFEQAADN ELSWLTDAEG KLLSMGEIRL EQDQTTAQLQ AQKIFSMDIM
RHKDAVDEIV KTGKAIMTSK NPEEKEILMA KTQTLLEKYG VVSQLNSERC LQLERAQSLA
TQFWETYEEL GPWLQETLNT FSQLPPPAIE YDTLRQQQED LRQMRELIAE HKPHIDKMNK
TGPQLLELSP VEGEPIREKY TATDQLYTKL KADVKQRAAT LDEAISKSTQ FHDKIDPMLE
SLERIAERLH QPPSISVEVD KIKEQITENK TVSVDLEKLQ PSYETLKQRG EEMIARSEGA
DKDLSAKAVQ DKLDRMVFLW NDIQALVEER EVKLLDVMDL ADKFWCDHTA LIVTIKDSHD
LLRELEEPGV DPSVVKQQQE FVEGFKEEID GLQEELDGVL NQGAELMTAC GEPDKPVIKK
SLDEVNTAWE NLNKTWKERG ERLEEAMQAA VQFQDGLQGM FDWVDILESK LDSMSPVGTD
LETVKQQIVE LKEFKGEAYQ LQIEMERLNH QAGLLLKKVT DEADRSAIQE PMSELKMLWD
NLDEKIISRQ HKLEGGLLAL GQFQHALDEL LAWMSHTEEL LNEQKNAGGD PKAIEIELAK
HNILQIDVLA HKSTVETVNK AGNDLVQSSA GEEASSLQSK LENLNQRWKA ILEKTEQRKQ
QLESSLLQAQ GFHGEIEDMQ QWLKDTERQL LASKAVGGLP DTAREQLNAH LELCSAFESK
EELYQELQNK GHQLLTMMPE GPDSNTEQDL ANLKEKWEAV QAKVAERKVK LEEALTVATD
FHNSLQDFIN WLTQAEQTLN TVSPASLILE TIMFQIDEHK MFVTEVNSHR EHIIELDKTG
THLKYFSQKQ DVVLIKNLLL SVQGRWEKLV QRSVERGRLL DDARKRAKQF HENFNKLMEW
LDESEKTLDS EVEIANDPDK IKTQLAQHKE FQKALGSKHS VYDTTTRTGR ALKDKTSLQD
DRQKLDDMLS ELRDKWDTVC GKSVERQNKL EEALLFSGQF TDALQALIDW LYRVEPQLAE
DQPVHGDIDL VLNLIDNHKV FQKELGKRTV SVQALKRSAR ELIENTHDDS SWVKVQMQEL
STRWETVCNL SVSKQTRLEQ ALGQAEEFHS AVHILLEWLA EAEQSLRFHG SLPDDEEALR
ALIEQHKVFM KKLEEKRVAL NKAASMGEAI LSICHPDSIT TIKHWNTIIK ARFEEVQAWA
RQHQQRLATA LTELLATQEL LENLLTWLQW AETNLNDKDK EPLPQEIEEV KNLIAEHQAF
MEEMTRKQPD VDKITKTHKR KAAAEPQIQS QIPVLDKGRT GRKRSPTQAM YASSTQAPIE
TKNPRVNLLV TKWQHVWLLA LDRRRKLNDA LDRLEELKEF ANFDFDVWRK RYMRWMNHKK
SRVMDFFRRI DKDQDGKVTR QEFIEGILSS KFPTSRLEMS AVADIFDRDG DGYIDYYEFV
AALHPNKDAY KPLTDADKIE DEVTRQVAKC KCPKRFQVEQ IGANKYRFYL GNQFGLVHCL
HDSLIGDETI ANRENQNLTP HLHVAVLESC ILFGDSQQLR LVRILRSTVM VRVGGGWMAL
DEFLVKNDPC RVHHHGSKML RSESNSSITQ SPIAKGRTNV ELREKFILPE GTTQVMASFR
YRGRRSRPSS RGASPNRSTS SQSLPVPTNP AATSTPKNPQ HITRNYDKPW LTNSKPSTPL
KSSDSFGSQG SSSESNPVQG SKLRLPGYLS GKGFQSGEEG SLISAAVLKA RTQTIGESRK
NSSRPGSKAG SRGSSRRGSD ASDFDISDIQ SVCSDVSETV GDSARATPRS ASRQHGGKPS
KIPTPQRRMT PTSKLAKGLK R
//
