ID A0A3Q4H4M3_NEOBR Unreviewed; 992 AA.
AC A0A3Q4H4M3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Signal peptide, CUB and EGF-like domain-containing protein 3-like {ECO:0000313|Ensembl:ENSNBRP00000016631.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000016631.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000016631.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q4H4M3; -.
DR STRING; 32507.ENSNBRP00000016631; -.
DR Ensembl; ENSNBRT00000017079.1; ENSNBRP00000016631.1; ENSNBRG00000012815.1.
DR GeneTree; ENSGT00940000153185; -.
DR OMA; TCALSCP; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000012815; Expressed in zone of skin and 2 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF2; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..992
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018790281"
FT DOMAIN 30..70
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 283..323
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 324..362
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 363..403
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 802..914
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 328..338
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 992 AA; 109815 MW; 2F9CA501C2CC7418 CRC64;
YVHMKLLLVV VLLLLVMLAL CLHGDHIAFY VDECAEALDN CSIDAICQNT LKSYKCICKS
GYKGDGKHCE DVDECATEYN GGCVHECINI PGNYRCTCYD GFRLAHDGHN CLDVDECSEG
NGGCQQICVN MMGSYECRCR EGFLLSDNQH TCIQRPKDGT KNEGPTCMDK NHGCAHICRE
TQKGGISCEC RPGFQLTRNM KDCKLTCNYG NGGCQHICEE TDQGPKCSCH MKFVLHSDGK
TCVETCAVNN GGCDSTCHDS VTGVRCSCPV GFTLQPDRKT CKDIDECRLN NGGCDHVCRN
TVGSFECSCK KGYKLLTNER TCQDIDECSF DRACDHFCVN SAGSFQCHCH KGYVLYGLAH
CGDIDECSIN RGGCKYGCVN TLGSYECTCP PGYKLHWNKK DCIEPVKCPP GLVAPKATLT
CSKTGKKESC SLTCASKAHY LAESDNSYSV SCGIPILRGK SPTRLNSNSS QSCIEALAPP
VKQTASFKIK NAKCHLHPKL PGRTEDRGRT LGQGGQPCSN CLVTFVNLKC DSSKKAKGRR
ARNPSNKEVT RITLELEAEV KPTDATGSCN LSCLRQRMEK QVKTYIKALK KSINQERFLI
RVAGLEYEVA QKLPQAVPIQ ENCGPGWERD SGRCVRCLSG SYYHGEQERC VQCPPGTFQE
KEGQLACDLC PGSDGHGPVG ARNISSCAGQ CPTGYYSSSG FKPCLPCPQG NYQPDLGRTL
CFPCGGGLST KREGASSFHD CEVKVDCSPG HYYNTTVHRC IRCPVGTYQT EFKQNYCISC
PGNTTTDFDG ATSVSQCKNR QCGGEMGEFM GYIESPNYPG NYPANVECIW NINPPSKRKI
LIVVPEIFLP SEDECGDVLV MRKNWSATSI TTYETCQTYE RPIAFTARSR RLWINFKSNE
ANSARGFQIP YVTYDEDYEQ LVEDIVRDGR LYASENHQEI LKDKKLIKTL FDVLAHPHNY
FKYTTRESNE LLPRSFIRLI SSKVSAFLRP YK
//
