ID   A0A3Q4H556_NEOBR        Unreviewed;       667 AA.
AC   A0A3Q4H556;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Xenotropic and polytropic retrovirus receptor 1 homolog {ECO:0000313|Ensembl:ENSNBRP00000015053.1};
GN   Name=XPR1 {ECO:0000313|Ensembl:ENSNBRP00000015053.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000015053.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000015053.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC       {ECO:0000256|ARBA:ARBA00009665}.
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DR   AlphaFoldDB; A0A3Q4H556; -.
DR   STRING; 32507.ENSNBRP00000015053; -.
DR   Ensembl; ENSNBRT00000015466.1; ENSNBRP00000015053.1; ENSNBRG00000011633.1.
DR   GeneTree; ENSGT00500000044895; -.
DR   OMA; LYQTMFL; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000011633; Expressed in testis and 4 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd14477; SPX_XPR1_like; 1.
DR   InterPro; IPR004342; EXS_C.
DR   InterPro; IPR004331; SPX_dom.
DR   PANTHER; PTHR10783:SF135; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1 HOMOLOG; 1.
DR   PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR   Pfam; PF03124; EXS; 1.
DR   Pfam; PF03105; SPX; 2.
DR   PROSITE; PS51380; EXS; 1.
DR   PROSITE; PS51382; SPX; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        213..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        252..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        297..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        330..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        450..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        484..505
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..177
FT                   /note="SPX"
FT                   /evidence="ECO:0000259|PROSITE:PS51382"
FT   DOMAIN          415..618
FT                   /note="EXS"
FT                   /evidence="ECO:0000259|PROSITE:PS51380"
FT   COILED          70..97
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   667 AA;  77711 MW;  3DC2D5258D46FAFB CRC64;
     MKFTEHLSAH ITPEWRKQYI QYEAFKEMLY AAQDQAPSIE VTDEDTVKRY YAKFEEKFFQ
     MCEKELAKIN TFYSEKLAEA QRRFATLQNE LQSSLDAQRE SSASGRGLRR RKTVFALSQQ
     ERCKHRNIKD LQLAFSEFYL SLILLQNYQR GLAFLCIHLC FCDCLVVFGG LNSIHRKQMM
     RCVPDILQQN HHECSFPFVV VQTNKDVLQT HHIICLCSVQ FCSVLIVLSP DWSLSLVAVG
     TDRSDVWPMI RIYRGGFLLI EFLFLLGINT YGWRQAGVNH VLIFELNPRN NLSHQHLFEI
     AGLLGVLWCV SLLSCLFSDK ILVPMQANPL ALYGLFFLFL INPFKTCYYK SRFWLLKLLF
     RVVTAPFHRV GFADFWLADQ LNSLVVVLMD LEYMICFYSF ELDWTKHNGL ISNDVCNSYS
     YGVRAVIKCL PAWFRFVQCL RRYRDTKRAF PHLVNAGKYS TTFFAVTFSA LYSTHKDAGS
     EAQIFFYLYI GCLAVSSCYT LVWDLKMDWG LFDRNAGENT FLREEIVYPH KAYYYSAIVE
     DVLLRFGWIL TVTVTTLVTF DGLSDIFATV LAPLEVFRRF VWNFFRLENE HLNNCGEFRA
     VRDISVAPLN ADDQTLLEQM MDQEDGVRNR QGKKSWKRSY SMSLRRPRLA SHLTARNTEV
     CVCSTKL
//