ID   A0A3Q4H6J1_NEOBR        Unreviewed;       499 AA.
AC   A0A3Q4H6J1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Rho guanine nucleotide exchange factor (GEF) 28a {ECO:0000313|Ensembl:ENSNBRP00000012092.1};
GN   Name=ARHGEF28 {ECO:0000313|Ensembl:ENSNBRP00000012092.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000012092.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000012092.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q4H6J1; -.
DR   Ensembl; ENSNBRT00000012433.1; ENSNBRP00000012092.1; ENSNBRG00000009368.1.
DR   GeneTree; ENSGT00940000155831; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000009368; Expressed in liver and 1 other cell type or tissue.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd14680; PH_p190RhoGEF; 1.
DR   Gene3D; 1.10.287.2510; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037819; ARHGEF28_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041020; PH_16.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR13944; AGAP007712-PA; 1.
DR   PANTHER; PTHR13944:SF22; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 28; 1.
DR   Pfam; PF17838; PH_16; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT   DOMAIN          50..152
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   COILED          313..417
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   499 AA;  57825 MW;  59F2BF8D334A7051 CRC64;
     VIAAVDMRVS EYERHQRLQE VFNRMENRSA AKLKSGHTFR KQDMMGPGQV LKHQGVLLWK
     TATGRLKDVL ALLLTDTLIF LQEKDQKYTF ATVDQKPPVI PLQKLIVREV ANEERGMFLI
     SASAAGPEMY EVHTSSKEER NTWMRLIREA VESCPEDEEE YTSESDEEKR AAEARFQKIQ
     KLQESLTSQD QQICSSLAEK LQIYAQLSVL SGRMEASLAE PRLLVQPHSE ELPQAAALLT
     AALEILMFTH ENCRRPINLV QNLTQLLYSL QAAVTIQDSC YEVQRLLLQE SGRPSPRAQR
     LHLPSVWGSA LQDQEKQRNL EKQKEEAAVA QRLHDRLRQE KERWERECQA RKSQQGAQES
     MLEEREKQCQ VAAERLRRER VELDEQLEEY QQNLERLREG QRSVERERER LDEQQKLLQC
     WKHGPQDSPP TANPHMFIPL DGQQVLGETE VIALSFTSES MSQKSMLSLS IEWPGRQQRV
     NHSLNLCKTH YSMACHRIR
//