GenomeNet

Database: UniProt
Entry: A0A3Q4H7Q6_NEOBR
LinkDB: A0A3Q4H7Q6_NEOBR
Original site: A0A3Q4H7Q6_NEOBR 
ID   A0A3Q4H7Q6_NEOBR        Unreviewed;       330 AA.
AC   A0A3Q4H7Q6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Caspase-6 {ECO:0000256|ARBA:ARBA00029534};
DE            EC=3.4.22.59 {ECO:0000256|ARBA:ARBA00029486};
GN   Name=CASP6 {ECO:0000313|Ensembl:ENSNBRP00000016098.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000016098.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000016098.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Strict requirement for Asp at position P1 and has a preferred
CC         cleavage sequence of Val-Glu-His-Asp-|-.; EC=3.4.22.59;
CC         Evidence={ECO:0000256|ARBA:ARBA00029356};
CC   -!- SUBUNIT: Heterotetramer that consists of two anti-parallel arranged
CC       heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a
CC       11 kDa (Caspase-6 subunit p11) subunit.
CC       {ECO:0000256|ARBA:ARBA00029473}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the peptidase C14A family.
CC       {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR   AlphaFoldDB; A0A3Q4H7Q6; -.
DR   STRING; 32507.ENSNBRP00000016098; -.
DR   Ensembl; ENSNBRT00000016532.1; ENSNBRP00000016098.1; ENSNBRG00000012429.1.
DR   GeneTree; ENSGT00940000155140; -.
DR   OMA; THCIHYS; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000012429; Expressed in testis.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00032; CASc; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR002398; Pept_C14.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   PANTHER; PTHR10454; CASPASE; 1.
DR   PANTHER; PTHR10454:SF206; CASPASE-6; 1.
DR   Pfam; PF00656; Peptidase_C14; 2.
DR   PRINTS; PR00376; IL1BCENZYME.
DR   SMART; SM00115; CASc; 1.
DR   SUPFAM; SSF52129; Caspase-like; 2.
DR   PROSITE; PS50207; CASPASE_P10; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
PE   3: Inferred from homology;
KW   Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT   DOMAIN          57..179
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
FT   DOMAIN          257..330
FT                   /note="Caspase family p10"
FT                   /evidence="ECO:0000259|PROSITE:PS50207"
SQ   SEQUENCE   330 AA;  37613 MW;  B31CCC11102BD60F CRC64;
     LKHTGCSAMA GTLETETKTK PNEIPSVKYT HTTLSLPYTV YYLSLDPAEE YKMCNKRSGL
     ALIFNQEKFF GRLGLNDRVD RYNLKERLKD LNFEVRCYDN YKQVDVLDEI AKAAEADHSD
     ADCFLLAFLS HREDNHVYCY DGKISIQDMM SMFKGDNCGD ITQLMPMSIF NLQACRGKLF
     DEGVTVTPAD AVFADASAIR TLPAGADFII CSSVAEGESS GIRLNLQLRG EVKKIYLIFH
     NHTRPPAMFC CFCHLIGYYS FRETKKGSWY IQALCEMLRK YDNSLEFTEL LTLVNRKVSM
     RNVPKSCDTQ LVGKKQMPCF ASMLTKKLYF
//
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