ID A0A3Q4H965_NEOBR Unreviewed; 926 AA.
AC A0A3Q4H965;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 2-like {ECO:0000313|Ensembl:ENSNBRP00000013022.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000013022.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000013022.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR AlphaFoldDB; A0A3Q4H965; -.
DR STRING; 32507.ENSNBRP00000013022; -.
DR Ensembl; ENSNBRT00000013390.1; ENSNBRP00000013022.1; ENSNBRG00000010104.1.
DR GeneTree; ENSGT00940000155783; -.
DR OMA; DACTNVN; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000010104; Expressed in brain.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15294; 7tmC_GABA-B-R2; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR041689; GBR2_CC.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR002457; GPCR_3_GABA_rcpt_B2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF18455; GBR2_CC; 1.
DR PRINTS; PR01178; GABAB2RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 468..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 705..728
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 468..750
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 743..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 194..221
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 775..802
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 756..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 926 AA; 105089 MW; F626063FEAEF9E15 CRC64;
CIKPMQPSHH AAVYPSHPPP LPFLVSSPPP HSVLPLAWFT RDGENLPIMV LMPMNESALM
SSISQGIEPA VQLAIQHIRE SGKYSFSLIT KIYDTECDNA KGLRAFFDAI CYGPKHLMIF
GGVCPSVTSI IAESLEGWNL VQLSFAATTP VLADKKKYPN FFRTVPSDNA VNPAVVKFLN
FYNWSRVGTL TQDVQRFSEV RNDLTNELEK ANIEIADTES FSNDPCGNVK KLKDNDVRII
IGQFDENLAS RVFCCAYNLN MFGSKYQWII PGWYQGNWWE QANNTNCTTK KLLTAMEGYI
SVDFEPLSPR QIKGISGRTP KEYEREYSRE LQQKGVEASK FHGFAYDGIW VIAKTLTRVM
ELLRIKQRQN MYHNFTVDDR EVGKMVLDVM NETNFFGVTG QVMFRNGERM GTIKFNQFQE
GQEVKVGEYN AIADVLDLIN NSIRFQGVEP PKDRTFVRLQ RRHINVPLYS ILSTITILGM
LMAGAFLFFN IKNRNHRLIK MSSPYMNNLI ILGGMLSYAS IFLFGLDGGF VSDKEFETLC
TVRTWILIVG YTTAFGAMFA KTWRVHAIFK NVKMKKKIIK DQKLLIIVGG MLLIDLCILI
CWQIVDPLRR TVEEYSLEAD PQGRDIAIRP FLEHCENTHM TIWLGIVYAY KGLLMLFGCF
LAWETRNVSI PALNDSKYIG MSVYNVGIMC IIGAAVSFLT RDQPNVQFCI VALVIIFCST
ITLCLVFVPK LITMRTNPDA ATQNRRLKFT QNQKKEDSKT STSVTSVNQA NTSRLDSLQT
DNHRLRMRIT ELDKELEEVT MQLQDTPEKT PYIKQNHYSD ANNILSIRNF TDDGEKSILK
NHLEQKPQAQ WGSMDPSRIN RGPLEDINSP EHIQRRLSLQ LPILHHAYLP SIGGVDASCT
SPNGSPGSSP RHRHMPPSYR VMVSGL
//
