ID   A0A3Q4H9C8_NEOBR        Unreviewed;       985 AA.
AC   A0A3Q4H9C8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=DENN domain-containing protein 3-like {ECO:0000313|Ensembl:ENSNBRP00000018421.1};
GN   Name=DENND3 {ECO:0000313|Ensembl:ENSNBRP00000018421.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000018421.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000018421.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q4H9C8; -.
DR   STRING; 32507.ENSNBRP00000018421; -.
DR   Ensembl; ENSNBRT00000018912.1; ENSNBRP00000018421.1; ENSNBRG00000014161.1.
DR   GeneTree; ENSGT00940000155784; -.
DR   OMA; QVWMGSQ; -.
DR   Proteomes; UP000261580; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12296:SF21; DENN DOMAIN-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT   DOMAIN          1..392
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
SQ   SEQUENCE   985 AA;  112741 MW;  06F3269F4EEE3122 CRC64;
     SVPKNIDLMA LPQLCFPGGL QVTSEQKEEQ FHFLVFTDIL GNKTHGVVMQ CYRPILEGMS
     LYRNSRGSSK CPKLFCAYSI CVISKHPYFT ALKDCLSCLL IQLRTCRLSD MEERVKEFAA
     KLTLVPIPPP GQLHLMFTIR PLTIILPSRE DKDHPVIDLD LHLPFLCFRP QQLLQVLSCL
     LQEQRVVLFS ADWARLTLMA ESLLLFLQPL LWQHPYVPVL AKGMLDFLMA PTAFLMGCHL
     SHFADVSAET DDLILINIDN GSLSTSTFDT VNLPDIPPVA AHCFTQRCKL LRIHFDLDQC
     HHASCTDISE QRAQRRTWQR SLNNDIQRIA LELIVNIFRD VSSHLNYEHR VFHSEEFLKT
     REPAEQLFYK KVLETHIFHS FLKDRLNRNM DSFARMELST RSEIEDKIID KENLSNLPSS
     PLCFLSLPAP STTPKPIKVF KLPDFPASLS FHSVQSYYIE LIQQLGKAIF SVQSENSAML
     ARYYYLRGLI NTLCSRRLDA LSDFQNLNKT DTAIFPTSLV TWLIDSLQRD ERQQAQRRPE
     LKRLILKVDN EKPLVEPDDH VKKFQLPCKP LYQEEFMRCV QECRIVRDVA TIQRLFDALT
     DSQPKQVDPE LFRVFYTFWK EMEAEAQDVN LPSDVIDRLD NNECVYKLSS CVKTSHGVGK
     IAMTQKRLFL LTEGRPGFLE ITKFRDIQEV KITSVPFLLV RIPSLRIQTS SRPEVFEANL
     KTETELWNLV IKEMWAGRKM ADQHKDPQYM TQALTNVLLI DAVTGCLQNQ RSITAAAKLA
     YFNKIRQEVP MIVPKTTSET LKHKINPSLD LAEPQTVHVL LYTPGQLTGT GKVGDMNPKL
     WVALSGGKVV VFDAASWSML QDCIQLGQSQ LNCMIGLVQE QVWIGSQDSV IYIIDTHSMS
     SNKQLTEHRH EVTGLAVDAT FFPSLLTYSC SRDGMILQWD SSSLKVKRQF LLSCDYLSSI
     QIHNSALWCC EYTLSPLSPS FKQCF
//