ID A0A3Q4H9I5_NEOBR Unreviewed; 966 AA.
AC A0A3Q4H9I5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A10 {ECO:0000313|Ensembl:ENSNBRP00000019605.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000019605.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000019605.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; A0A3Q4H9I5; -.
DR STRING; 32507.ENSNBRP00000019605; -.
DR Ensembl; ENSNBRT00000020121.1; ENSNBRP00000019605.1; ENSNBRG00000015068.1.
DR GeneTree; ENSGT00940000156972; -.
DR OMA; VFIMMGV; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000015068; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF32; SODIUM-DRIVEN CHLORIDE BICARBONATE EXCHANGER; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 464..486
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 498..521
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 541..565
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 577..595
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 677..695
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 715..732
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 763..782
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 803..827
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 863..882
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 889..908
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 935..952
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 140..396
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 435..941
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 47..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..71
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 966 AA; 109109 MW; 1DC481C672E15EE4 CRC64;
GFQTPLNRND DEAVVDRGGT RSEQRTNFEQ EDLEGHRTLY IGVHVPLGST RHRSHRRHRH
HGNKYSRRRN KERVRTLVEG RESPIYDTPS QRVQFLLGAE DDDEEHIPHD LFTEMDEICV
REGEDSEWRE SARWLKFEED VEDGGERWSK PYVATLSLHS LFELRCCIIN STVLLDMRAS
TIEEIADMVL DHQELYSPLG DELRKKVRET LLKQHHHQNQ KKLANRLPLV RSIADIGRKT
SELHLDKNGQ LAASQSQLAV QDGKGDISRD TSSVDFSKID IHFMKKIPPG AEACNVLVGE
LEFLNKPVVA FVRLSPAVLL NGLAEVPIAT RFLFILLGPL GRGSQYHEIG RSIATLMTDE
VFHDVAYKAK DRNDIIAGID EFLDQVTVLP PGEWDPSIRI EPPKNVPSQK RKKSNILPNG
LNADANIYSF IYLPRWFGGL ILDIKRKAPH YLSDYTDAFS LQCVASFLFL YCACMSPVIT
FGGLLGEATE GRISAIESLF GASLTGIAYS LFAGQPLTIL GSTGPVLVFE KILFKFCKEY
GLSYLSLRTC IGLWTAFLCI LLVATDASSL VCYITRFTEE AFASLICIIF IYEALEKLVH
LGKHYPFNKN NNLEKLTLYS CSCVEPSDPT NGTLKYWEMN NITASEIYWE ALEGCIENRG
EFVGSACGPQ GPYVPDVLFW CVILFFSTVF MSAFLKEFKF SNYFPTKVRS VISDFAVFIT
ILTMVLVDYA LGVPSPKLKV PSVFKPTRDD RGWFITPLGP NPWWTAVITV VPAMLCTILI
FMDQQITAVI INRKEHKLKK GCGYHLDLFM VGVMLGVCSL MGLPWFVAAT VLSITHVNSL
KLESECSAPG EQPKFLGIRE QRFTGLMIFA LMGCSVFMTS VLKFIPMPVL YGVFLYMGAS
SLRGIQFYDR LRLFGMPAKH QPDFIYLRHV PLRKVHLFTI IQLSCLVLLW TIKTSRAAIV
FPMMVS
//
