ID   A0A3Q4HA36_NEOBR        Unreviewed;       912 AA.
AC   A0A3Q4HA36;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Kinesin-1 heavy chain-like {ECO:0000313|Ensembl:ENSNBRP00000017018.1};
GN   Name=KIF5B {ECO:0000313|Ensembl:ENSNBRP00000017018.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000017018.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000017018.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR   Ensembl; ENSNBRT00000017478.1; ENSNBRP00000017018.1; ENSNBRG00000012740.1.
DR   GeneTree; ENSGT00940000154801; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000012740; Expressed in testis.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd01369; KISc_KHC_KIF5; 1.
DR   Gene3D; 6.10.250.1590; -; 1.
DR   Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR47968; CENTROMERE PROTEIN E; 1.
DR   PANTHER; PTHR47968:SF73; KINESIN HEAVY CHAIN ISOFORM X1; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT   DOMAIN          9..313
FT                   /note="Kinesin motor"
FT                   /evidence="ECO:0000259|PROSITE:PS50067"
FT   COILED          403..507
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          586..855
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   BINDING         85..92
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ   SEQUENCE   912 AA;  105021 MW;  8AA6E749E9025788 CRC64;
     MGDAAAECTI KVVCRFRPLN SSEVARGDQY IPKFKGDDCV LMGKPYYFDR VFQSKTTQEE
     FYNAVAQKIV KDVLEGYNGT IFAYGQTSSG KTHTMEGKLH DPEMMGIIPR IVQDIFNYIY
     SMDENLEFHI KVSYFEIYLD KIRDLLDVSK TNLPVHEDKN RVPYVKGCTE RFVCTPDEVM
     EAIDEGKNNR SVAVTNMNEH SSRSHSIFLI NIKQENSKXX XXXXXVGKTG AEGTVLDEAK
     MINKSLSALG IVISALAEGS SYIPYRDSKM TRILQDSLGG NCRTTMVICC SPSAYNDAET
     RSTLLFGQRA KTIKNQVTMN VELTAEQWKS KWEKEKEKNK TLRNTVTWLE NELNRWRSGE
     DHRLYYGQVM CGSLNIALWQ ENYVNETLLD FSFPLPFLQD DEINQQSQLV ETLKQQMLDQ
     EELLASSRRD HHTLQTELNR LLAENEASKE EVKEVLQALE ELAVNYDQKS QEVENKTKEF
     EALSEELNEK SSSLASIDSE LQKLKEMTNH QKKRVTEMMS SLLKDLAEIG IAVGSNDIKQ
     QESSGLIDEE FTVARLYISK MKSEVKTMVK RSKLLESTQT ETTQKLDETE SDLTACQLRI
     SQQEAKIKSL TESLQNVEQK KRQLEENVDS LSEEIVRTRA QEKVNAMEKE NEIQSANEVK
     EAVEKQIQTH REAHHRQISS LRDELDAKEK LITDLNQQIM LEQERLRVEH EKLKAADQEK
     SRHLINDRRE QARQDLKGLE ETVARELQTL HNLRRLFVQD LSTRLKKVQM DSESSAAQKQ
     KISFLENNLE QLTRVHKQLV RDNNDLRSEI PKMEKRLRAT AERVKALETA LKEAKENAAH
     DRKRYQQEVE RIKDAAKPKN MGRRGSAQIA YQTWSAARGS HKLQCQQVQP HPEQPPYRKT
     CTLFPCSPRF MN
//