ID   A0A3Q4HAB3_NEOBR        Unreviewed;       112 AA.
AC   A0A3Q4HAB3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=D-dopachrome decarboxylase {ECO:0000256|ARBA:ARBA00038884};
DE            EC=4.1.1.84 {ECO:0000256|ARBA:ARBA00038884};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000013492.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000013492.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Tautomerization of D-dopachrome with decarboxylation to give
CC       5,6-dihydroxyindole (DHI). {ECO:0000256|ARBA:ARBA00037460}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC   -!- SIMILARITY: Belongs to the MIF family. {ECO:0000256|ARBA:ARBA00005851}.
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DR   AlphaFoldDB; A0A3Q4HAB3; -.
DR   STRING; 32507.ENSNBRP00000013492; -.
DR   Ensembl; ENSNBRT00000013866.1; ENSNBRP00000013492.1; ENSNBRG00000010461.1.
DR   GeneTree; ENSGT00940000166931; -.
DR   OMA; VVITFHD; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000010461; Expressed in heart and 8 other cell types or tissues.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.429.10; Macrophage Migration Inhibitory Factor; 1.
DR   InterPro; IPR001398; Macrophage_inhib_fac.
DR   InterPro; IPR014347; Tautomerase/MIF_sf.
DR   PANTHER; PTHR11954; D-DOPACHROME DECARBOXYLASE; 1.
DR   PANTHER; PTHR11954:SF22; D-DOPACHROME DECARBOXYLASE; 1.
DR   Pfam; PF01187; MIF; 1.
DR   SUPFAM; SSF55331; Tautomerase/MIF; 1.
PE   3: Inferred from homology;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580}.
SQ   SEQUENCE   112 AA;  12115 MW;  D487EAA49F640D6F CRC64;
     VNKVDSVSHL ARAAFFLSRA SMRVSVSLVQ RMNVVVTPGL PMLMAGSASP CVILSVSAIG
     VTDTAEKNKE HSAKIFEFLT KELDLSQDRI VIVFNALEPH QVGKKGTVMS FL
//