ID A0A3Q4HBY5_NEOBR Unreviewed; 1629 AA.
AC A0A3Q4HBY5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Kinesin-like protein KIF1A-like {ECO:0000313|Ensembl:ENSNBRP00000020660.1};
GN Name=KIF1A {ECO:0000313|Ensembl:ENSNBRP00000020660.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000020660.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000020660.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR STRING; 32507.ENSNBRP00000020660; -.
DR Ensembl; ENSNBRT00000021219.1; ENSNBRP00000020660.1; ENSNBRG00000015823.1.
DR GeneTree; ENSGT00940000156474; -.
DR OMA; CLAVQVI; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000015823; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008207; Sig_transdc_His_kin_Hpt_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS50894; HPT; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00110};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 5..334
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 337..430
FT /note="HPt"
FT /evidence="ECO:0000259|PROSITE:PS50894"
FT DOMAIN 495..551
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1509..1607
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 409..436
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 607..656
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 89..96
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
FT MOD_RES 376
FT /note="Phosphohistidine"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00110"
SQ SEQUENCE 1629 AA; 184823 MW; 19B2F33833A51AFE CRC64;
MAGASVKVAV RVRPFNSREI GKESKCIIQM SGNTTSEYTR VQLVAPRLFS EDLPEDVNYA
SQMQVYRDIG EEMLLHAFEG YNVCIFAYGQ TGAGKSYTMM GRQEKDQQGI IPLLCEDLFT
KINDSNNENS MSYSVSYMEI YCERVRDLLN PKNKGNLRVR EHPLMGPYVE DLSKLAVTSY
NDIQDLMDSG NKARTVAATN MNETSSRSHA VFNIIFTQKK HDMETDNTSE KVSKISLVDL
AGSERADSTG AKGTRLKEGA NINKSLTTLG KVISALGELR YANATRKKEL MKYICVSVLG
GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIRCNAVI NEDPNNRLVR ELKEEVARLK
DLLYAQGLGD IIEMTHAMTG MSPSPSLSAL SSRAGSISNL HDRIFSPASE EAIERLKETE
KIIAELNETW EEKLRRTEAI RMEREALLAE MGVAMREDGG TVGVFSPKKT PHLVNLNEDP
LMSECLLYYI KDGITKVGRE NAKTRQDIVL SGHFIKDEHC TFSSTTGPQG EGCIILDPCE
GAETYVNGKR VTSPIVLRSG NRIIMGKSHV FRFNDPEQAR LERERTPCAE TPVEPVDWAF
AQRELLEKQG IDMKQEMEQR LQELEDQYRK EREEASNLLE QQRLDYESKL EALQKQVDSR
YLESPEEEEE PEEEVPWTKR ETELALWAFR KWRFYQFTSL RDLLWGNAIF LKEANAISVE
LKKKVQFQFV LLTDTLYSPL PPDLLPPSEA KERERRPFPR TIVAVEVQDQ KNGATHYWTL
EKLRQRLDLM REMYDRAAEL PSSAVEDCDH ALTGGDPFYD RFPWFRLVGR AFVYLSNLLY
PVPLVHRVAI VSEKGEVKGF LRVAVQAISA DEEAPDYGSG VRQSGTAKIS FEDKQFEKFQ
TESCPANLSH SNTSQEELRI VEGEGQNAET GISADEVNNN TCLGLDLPLD LSPEKALSHL
KIGSTFTFRV TVLQASSISA EYADIFCQFN FIHRHDEAFS TEPLKNTGRG PPLGFYHVQN
ITVEVTKSFT EYIKTQPIVF EVFGHYQKQP FPPLCKDLIS PLRPSRRQFP RVMPLSKPVP
ATKLNTLTRS TAGPCHAKYD LMVFFEICEL EANGDYIPAV VDHRGGMPCH GTFLLHQGIQ
RRIRVTIAHE TGNDIEWKEV KELVIGRIRN TPEADETIID PNILSLNILT SGYVWPKHDD
KTFYRFEAAW DSSMHNSLLL NRVTPYGEKI YITLSTYLEM ENCTQPTVIT KDFCMVFYSR
DTKLPASRSI RNLFSTGCLR PSESNRVTGV YEITLCHVAD NGSPGMQRRR RRVLDTSVAY
VRGEENLAGW RPRSDSLILD HQWELEKLSL LQEVEKTRHY LLLREKLEAT LHAGQDALYK
NGDIIDFAKS PVLSHSPSSS PAPDSPNQRQ RELAAKCLRL LMHTFNREYS QLFSECMSVS
FVLNCLLDCF VCVCLSSCLL SEMSASLMRE SSSSTLSTLT PSSTCPSLVE GHYDISYSFC
NSFNIRSPIV SKKGYLHFLE PHTSGWVRRF VVVRRPYVYL YRSERDSVER AIINLSSAKV
EYSEDKQTLL RTPNTFAVCT EHRGILLQAA NDKEMHDWLY AFNPLLAGTI RSKLSRRKSV
QSYPSAQRM
//
