ID A0A3Q4HCG4_NEOBR Unreviewed; 356 AA.
AC A0A3Q4HCG4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Protein shisa-9B-like {ECO:0000313|Ensembl:ENSNBRP00000019501.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000019501.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000019501.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Regulator of short-term neuronal synaptic plasticity in the
CC dentate gyrus. Associates with AMPA receptors (ionotropic glutamate
CC receptors) in synaptic spines and promotes AMPA receptor
CC desensitization at excitatory synapses.
CC {ECO:0000256|ARBA:ARBA00037492}.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendritic spine membrane
CC {ECO:0000256|ARBA:ARBA00029429}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00029429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the shisa family. SHISA9 subfamily.
CC {ECO:0000256|ARBA:ARBA00038448}.
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DR AlphaFoldDB; A0A3Q4HCG4; -.
DR STRING; 32507.ENSNBRP00000019501; -.
DR Ensembl; ENSNBRT00000020015.1; ENSNBRP00000019501.1; ENSNBRG00000015026.1.
DR GeneTree; ENSGT00940000163663; -.
DR OMA; EKTHRPH; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000015026; Expressed in brain.
DR GO; GO:0032591; C:dendritic spine membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31774:SF1; PROTEIN SHISA-9; 1.
DR PANTHER; PTHR31774; PROTEIN SHISA-9-RELATED; 1.
DR Pfam; PF13908; Shisa; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..356
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018669604"
FT TRANSMEM 133..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 251..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 356 AA; 39626 MW; 41CD5EE47DBC46FA CRC64;
MRGTELLLGY FLVKVMVCDA EGEPGQTIDD YIIPGFNDSM EAEIGVTETP HVEDKCRGYY
DVMGQWDPPF VCRTGSYLYC CGTCGFRFCC AFKSSRLDQT TCKNYDTPPW MMTGRPPPKV
DVALESAKDK TNLIVYVICG VVAIMALIGI FTKLGLEKTQ RPHRENMSRG NCNSVSALIT
IDCPSLESNQ MNNAAHVPTL VSQPYPGVGP IISPYEDPKD LNKYTTLKAV AEKANDSFHN
NRRQVIEMTA KGSLPMEGVD MEPEPSNPYS PPRQLSKQNG HKYKSSKSHS SQSLYYSASS
APSPGLLRSW ESKDTLGLRQ SYGPKKLCIT EKELDTIRYM PPQPYYVTNS KTEVTV
//