ID   A0A3Q4HD38_NEOBR        Unreviewed;       740 AA.
AC   A0A3Q4HD38;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Zinc transporter ZIP10-like {ECO:0000313|Ensembl:ENSNBRP00000021090.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000021090.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000021090.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000256|ARBA:ARBA00006939}.
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DR   AlphaFoldDB; A0A3Q4HD38; -.
DR   STRING; 32507.ENSNBRP00000021090; -.
DR   Ensembl; ENSNBRT00000021661.1; ENSNBRP00000021090.1; ENSNBRG00000016135.1.
DR   GeneTree; ENSGT00940000160335; -.
DR   OMA; HATAHNH; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000016135; Expressed in zone of skin and 3 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR003689; ZIP.
DR   PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR   PANTHER; PTHR12191:SF37; ZINC TRANSPORTER FOI; 1.
DR   Pfam; PF02535; Zip; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..740
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018601655"
FT   TRANSMEM        451..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        643..664
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        670..691
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        711..730
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          140..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          298..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          522..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..275
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        298..312
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        328..355
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        522..539
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  83766 MW;  3E1577CF1FE79C1E CRC64;
     MRVHMHTKFC FLCVLTFLFH QCSHCHEGGH HHQHDGHHHN DHDSAHSDLQ ISEAPYVRGV
     TESPGSKSGH AGDALEEEQR FYIQQLFRRY GQEDRLDFKG FQSLLFSLGL GEVKVVGLDH
     EDLGHDHVAH LEVLDMLHGH SSTNAGHSHG QGQGHRHSHT TQMRPHQKQD SQHPHTEGAP
     TRCSQTTAGP TEHEHDHEHD HDHDHDHEHD HDHNHDHNHT KVEENDHQHD THDFGDHNNH
     NHTHDEEHKH QQVNHRDLSS QPHPDHDHSN HSDHEHDYNH IHEVHTDIGG THLDQETLEP
     SQVPQRLQPT PTENRPKKPR KPGRVRGQRG RDKTTSSHTP ASDDHDHDNT HDHNHTHGHS
     HSHKDKREAP GALPCLNLTQ LLTYYGLNPD SLISPRQFAY LCPALLYQID RRVCILHYEQ
     MDVEQESQGQ HDHSKHGADE EEDMATAFDG VWKGLTALAG IYLLFIIEHC IGMFKHYKDQ
     RKKVNEEGKI GRKLSDHKLN RRSDAEWLHL KPLNEHNDTQ LTELQTPDSP TNKTPLAPAN
     LGQSPAKENG RKTKKHSHGH GHSHGGNCHS DQEMKDAGIA SIAWMVIMGD GMHNFSDGLA
     IAAFSANLTG GISTSVAVFC HELPHELDFA VLLKAGMSVK QAIVYNLLSA LMAYVGMLIG
     TAVGQYTHNV TNWIFAITAG MFLYVALVDM LPEMLHGDSE EHKRCQLGHF ILQNLGMLTG
     FAIMLLIAIF EDRIVFDFGF
//