ID A0A3Q4HDY5_NEOBR Unreviewed; 4570 AA.
AC A0A3Q4HDY5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Plectin-like {ECO:0000313|Ensembl:ENSNBRP00000021435.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000021435.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000021435.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR STRING; 32507.ENSNBRP00000021435; -.
DR Ensembl; ENSNBRT00000022013.1; ENSNBRP00000021435.1; ENSNBRG00000016348.1.
DR GeneTree; ENSGT00940000162855; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000016348; Expressed in zone of skin and 7 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 3.90.1290.10; Plakin repeat; 6.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF21; EPIPLAKIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00681; Plectin; 16.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00250; PLEC; 33.
DR SMART; SM00150; SPEC; 6.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF75399; Plakin repeat; 7.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 55..163
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 176..281
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 838..895
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1388..1424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1506..1577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1654..1673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1686..1735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1849..1870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2037..2111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2120..2139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2145..2213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2433..2454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2489..2515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4281..4317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4511..4570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 791..821
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1163..1207
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1282..1319
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1514..1577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2037..2079
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2096..2111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2145..2183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2195..2212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2433..2451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2489..2505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4281..4314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4570 AA; 521967 MW; A1724366049470E7 CRC64;
MAEVDDTVQA DRPSWYGGLE RGFLYRRTNY IHEMNCSEVG SHLYSRMCCA DERDRVQKKT
FTKWVNKHLV KHWKAEAQRH ITDLYEDLRD GHNLISLLEV LSGETLPREK GRMRFHKLQN
VQIALDFLKH RQVKLVNIRN DDIADGNPKL TLGLIWTIIL HFQISDIQVN GQSDDMTAKE
KLLLWSQRMV EGYQGLRCDN FTGSWRDGKL FNAIIHKHRP TLIDMSQVYR QTNQQNLEQA
FSVAERELGV TRLLDPEDVD VPHPDEKSII TYVSSLYDAM PRVPDVQDGV KANELEMRWQ
EYYELVTMLL QWIRHHILVF EERKFPTSYE EIEVLWRQFL KFKETELPAK EADKNRSKHI
FKSFEGAVQA GQVKVPPGYH PLDVEKEWGR LHVAILERER LLRTEFERLE RLQRVVSKVQ
MESGVCEEQL NQVETLLQTD VRLMSSGKPA QHTAEMEADL EKAEGMIRLL FNDVQLLKDG
RHLQAEQMYR RVYRLHERLV NLRSEYNLRL KSGVTITQIP MTQIPMTQVH TTQVHTAQVL
QQAPVRVRPQ LDEVTLRYIQ DLLSWVEENQ RRVDEGQWGS DLPSVESQLG SQRGLHQCVE
EFRSKIDRAK ADESQISPAS KAAYRDYLGK LELQYGKLLN SSKARLRSMD QLHAFVTAAT
KELMWLNEKE EEEVNYDWSE RNTNMAAKKE NYSGLMRELE LREKKVNGVQ ATGDKLLRDG
HPAKKTIEAF TGALQTQWSW ILQLCCCIET HLKENTAYYQ FFSDVKEAEE KIKKIQDTMK
RKYTCDRSIT VTRLEDLLQD AADEKEQLNE FKTHLEGLKR RAKTIVQLKP RNPATPIKGK
LPVQAVCDFK QMEITVHRGD ECALLNNSQP YKWKVLNDKG NESSVPSICF LIPPNNRDAV
NSVAGLDGNL QRLQNMWQTL FVDMKSLLSW QYLMRDIHII KSWNISMFKT LRVEEYRLAL
RNLEQHYQDF LRDSQDSQMF GAEDRMQVES NYNLANQHYN TMASSAEQDY VPPRAGEQDE
TVCRTYLTKI KDLRLRLEGC ETRTVTRLRQ PVDKEPLKAC ALKTAEQMKV QSELEGLKND
LGSIAEKTEE VLASPQQSSS APMLRSELDM TLKKMDHVYG LSSVYLDKLK TIDVVIRNTK
DAEDTLKSYE TRLRDVSKVP GDEKEVEDQR NQLKSMRAEA EADQVIFDRL QDELRRATAM
NDKMTRIHSE RDADLEHYRQ LVGNLLERWQ AVFAQMDLRQ RELGLLGRNM NSYRESYEWL
IRWLEEAKQR QEKLQAVPIG DSKALREQLA QEKKLLGEIE KNKEEIENCQ KNAKAYIDSV
KDYEFQILTY KALQDPIASP LKKPKMECAS DNIIQEYVTL RTRYSELLTL TSQYIKFITD
TQRRLEEEEK ASEKVKEAER KRMAEMQAEL DKQKQLAEAH AKSVAKAEKE AEELKLKMKE
DANKRQDVAV DAEKQKQNIQ QELHQLKSLS EQEIKSKSQQ LEEALISRTK IEEEIHIIRI
QLETTMKQKG TAETELQQLR DKAAEAEKLR KAAQDEAERL RKQVTEETQK KKNAEDELKR
KSEAEKEAAK QKQKALDDLQ KFKLQAEEAE RRMKQAEDEK LRQIKVVEEV AQKSAATQLQ
TKAMSFNEQA TKLEESLKKE QGTVLQLQEE AEKLRKQQEE ANKAREQAEK ELETWRQKAN
EALRLRLQAE EEAQKKSQAQ EEAERQKVEA ERDAKKRAKA EEAALKQKEN AETELERQRK
FAEQIAQQKL SAEQECIRLK ADFEHAEQQR GLLDSELQRL KNEVNAAEKQ RKQLEDELAK
VRSEMDALLQ MKTEAEKVTL SNTEKSKQLL ESEAQKMKQL AEEAARLRSV AEEAKKQRQT
AEDEAAQQRA EAEKILKEKL SAINEATRLK TEAEIALKAK EAENERLKRK AEEEAYQRKL
LEDQAAQHKL EIEEKITHLK SSSDSELVRQ KTIVEETLRQ KKVVEEEIHI IRINFEKASK
EKSDLEGELK KLKDLADETE KSKLKAEKEA DKLKKLAAEE EKKRKEAEEK VKRITAAEEE
AARQCKAAQE EVERLKKNAE EAKKQKEQAE KEAEKQVIVA KEAAQKCSAA EQKTQDVLSK
NKEDSLAQEK LKDEFKNAKK LAEAAQKAKE KAEKEAALLR QKAEEAEKLK KAAEEEAAKQ
AKAQKDAEKL RKEAEEEASK RAAAEQAALK QKQQADAEMA KHKKEAEQAL TQKSQVEKEL
TLVKLQLDET DKQKKVLDKE LQRVKGEVND AVKQKAQVED ELSKVKIQME ELLKLKLKIE
EENRRLMKKD KDSTQKLLAE EAEKMKSLAE EAARLSVEAE EAARQRQIAE SDLAEQRALA
EKMLKEKMQA IQEATKLKAE AEELQKQKDQ AQEKAKKLLE DKQQIQQRLD KETQDFQKSL
EAERKRQFDV AAEAEKLKVK VKELSDAQAK AETEAKKFKK QADEAKSRLQ QTEKQTTEIV
VQKLETQRLQ STREADDLKK ALADLEKEKE KLKKDAEELQ KKSKEMENAQ QAQIEQQKAI
LQQSFLTEKE VLLKREKAVE DEKKKLEKQF GDEVNKAKTL KDEQERQRKL MDEEKKKLQA
IMDEAVKKQK EAEAEMKNRE RELDVLEKKR IEQEKLLEEE NKKLRERLQN LEVVSKQGSS
TTKEIEVQTD EVPEEQLVAM TMVGTTKKVF NGSVEDGLKK DGESMLAFDG IREKVPAERL
HEVGVLTKKE FDKLKKGKVS VQELGKTEKL KPYLKGESCV GGVLTPSKEK MSLYQAMTEK
KITPNTATML LEAQAASGFI VDPVKNKLLS VDEAVKEELI GPELHDKMLS AERAATGFKD
PFTGAKISLF EAMKKGLIEK EQATKFLDVQ LATGGIIDPI NSHRVPLQTA YKQGQFDADI
NKKLSDPSDD CKLFIDPSTQ EQLAYKQLLE KCTKDAETGL LILPVTEKAA QTERTYTDVE
TKDIFSKSNI DVPFGKFKGK TVTIWEVINS EYFTEEQRRE LIRQYKTGKI TVEKIIKIVI
TVVEDKEKNK ENVFNGLRAP VSANELLESK VINKDVFNKL SNGKITIKEI SEMDPVKKAL
NGTPSIAGLF YEPTKEKMPF YQAMKKELLS PEMALNLLEA QAATGFIIDP VKNERVPVDE
AVKSSLVGPE LHERLLSAER AISGYRDPYT GKNVSLFEAM NKGLIKREHG IRLLEAQLST
GGIIDPIKSY RIPHEIACKR GYFDEEIAKA LNTNTDETKV FCDPNSQEDA SYAQLLNKCV
IDKETGLPLL SLSKKAPKPK EDKQITEAKT KEALNQATME LEYGPFKGRK VTIWEIIHSE
YITEEQRIEL IRQYRMGYVT IEKLIKIVIT MVDEKEDKTK EEACFEGLRA PVTASSLLDS
NIIDKATFEQ LQNGKKTPKE VSETDKVRKY LRGTDRIDGI TMGDSDEKLS IYQAIKKGIL
QQSTGLTLLE AQAGTGFITD PVKNLKYSVD DAVKAGVVGP ELHEKLLSAE KAVTGYKDPY
TGNTISLLQA MKKELVLREH AIPLLEAQFA TGGIIDPVSS HRVPNDVAIQ RGYFSKQMAK
SFSEPTGDVK GFTNPNTNGN VTYKELLEKC KRDPNAGLCY LPLSKVESPA PVEKSYQYSE
EQAQTDLANT QIDIPLKSFA GKSMTIWEVM NSYFLPAEER RRLMEQYRLG QITRERMLIL
IIEIIEQRET LKSEQSMSCD VIRRRVTIDE LYNARIIDLH TYNLLKQEKM NIREVMEMPT
VKQYLFGTGC IAGIMSDSPP KISIYQAMKN GKIKPEVALN LLEAQAATGF MIDPVKDELL
TVDEAVRKGL VGPELHDKLL SAERAVTGYK DPYTGKVISL FQAMKKDLIS EDYALRLLEA
QNATGGLMDP EYYFHLPIDV AMQRGYINKE TLERITEPTA DVRGYTDPTT DEKQSYAQLL
KRCRVDKESG LRLLSLADRR LLFRGLRKQI TVDELLRSQI INQKTYSDLT EGIITVEEVS
RDVKKYLEGT SCIAGVFVES GKDRLSIYQA MKKNMIRPGT AFELLEAQAA TGYVIDPIKN
LKLNVNEAVK MGVVGPEFKD KLLSAERAVT GYKDPYSGKV ISLFQAMKKG LILKDHGIRL
LEAQIATGGI IDPQESLRLP VETAYERGLF DEEMNGILTD PSDDTKGFFD PNTEENLTYL
QLMERCMIDP ETGLALLLLK EKKRERKTSS KSSVRKRRVV IVDPESGKEM SVYEAYQKGL
IDHQTYLELA EQECEWEEIT ITSSDGVVKS MIIDRRSGRQ YDIDDAISRG LIDKSALDQY
RSGMLSITEF ADMLSGNMSG SRSRSSSFGS SSSYPMSPIP SIKTPATTWT DPTEETGPIA
GILDTETLEK VSVTEAIHRN LVDNITGQRL LEGQACTGGI IDPNTGEKFS VADAMNKGLV
DKIMVDRISL AQKAYNGFED PRTKTKMSAA QALKKGWLYY EAGQRFLEVQ YLTGGLIEPD
ATGRVSIDEA VRKGTLDART AQKLRDVSAY SKYLTCPKTK LKISYKDAIE RSMTEEGTGL
RLLEASSQSS KGLYSPYSIS GSGSATGSRS GSRTGSRSGS RRGSMDATGS SFTTTFSSSS
YSSPSYGRRY
//
