ID A0A3Q4HE42_NEOBR Unreviewed; 1069 AA.
AC A0A3Q4HE42;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000015047.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000015047.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Photoreceptor outer segment membrane
CC {ECO:0000256|ARBA:ARBA00004451}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004451}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR AlphaFoldDB; A0A3Q4HE42; -.
DR STRING; 32507.ENSNBRP00000015047; -.
DR Ensembl; ENSNBRT00000015460.1; ENSNBRP00000015047.1; ENSNBRG00000011606.1.
DR GeneTree; ENSGT00940000165991; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000011606; Expressed in camera-type eye and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06371; PBP1_sensory_GC_DEF-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF349; RETINAL GUANYLYL CYCLASE 2; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Vision {ECO:0000256|ARBA:ARBA00023305}.
FT DOMAIN 516..770
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 842..972
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 779..810
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1069 AA; 119892 MW; 43CDE24F7BE07891 CRC64;
MRQQRRAFTS LPQTWKKTPE SSPDFCLSYS AFIIKSSPSA HPPSSLNPCC CAPNLRPSLT
PLSLCGLLRF VFILLASLCL LPCPTQAAWF RVGVVGPWGC DPLFAKALPS VAAQLAVNRI
NKDASLSYAV TFEYAVLQEP CETSRALEAF VGFHTKASGY IGPANPGYCD AASMLSKGWN
KALFPWGCVG YELDDVRSHP TFARSMARPT WVLLSVMSYF RWAHIGIISS SEDIWMETAT
KVADALRSHG MPVRLVTFME NTPHGIRRAL TKVRKMSEIR VVILCMHSVL IGGTAQKLLL
ETAYDMQMID GSLVFLPYDT LLYSLPYHNV TYPALKRNNK LLRAYDAVLT VTIDSPRVSF
YEAYREAMER GEVASTLKPQ QVSPLFGTIY NSVIFMAHAV HRVREFREWM SGGNLARQSQ
NLAFQGFSHP IKTNGSGAAL LEYLILDTDG ISWELKPTHR IDMEIGMVRF LGKDIHFPRG
YGPKKDASCW FTPGVICSGG EDVATLTSSI GLLLRRINQI RLVRGPNKIL LTLADVTFIN
PSLSNKGDWA WLKRLPYGTF SSINPKTSDV FELMKDMRHE NVNPFLGFFH DCGVFAIVTE
FCSRGSLEDL LLNEDVKLDW MFKSSLLLDL IKGMKYLHHR GVSHTRLKSR NCVVDGRFVL
KVTDYGYNEV LEAQRFPYIE PHADELLWTA PEILRSGQAG LHGTLPGDVY SFAIIMQEVV
KLCKPPPLCR PVVSPDYAPM ECIQLMKQCW NEQPDKRPAF DEIFDQFKNI NKGKKTNIID
SMLRMLEQYS SNLEELIRER TEELEIEKQK TEKLLTQMLP PSVAEALKVG GTVEPEYFDQ
VSLYFSDIVG FTTISANSEP IEVVDLLNDL YTLFDAIIGN HDVYKVETIG DAYMVASGVP
VPNGIRHATE IANMALDILS AVGTFKMRHM PDVPVRIRIG LHTGSCVAGV VGLTMPRYCL
FGDTVTTASR MESSGMPYRI HVHQSTVKVL HQLNLGYKLE LRGRTEVRGK GIEETYWLVG
RDGFTKPLPV PPDVKSGQMA HGLQMAEIAQ YKKQKAEKQQ QEQLAKKKN
//
