ID A0A3Q4HEM8_NEOBR Unreviewed; 1132 AA.
AC A0A3Q4HEM8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=SAM and SH3 domain-containing protein 1-like {ECO:0000313|Ensembl:ENSNBRP00000021725.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000021725.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000021725.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q4HEM8; -.
DR STRING; 32507.ENSNBRP00000021725; -.
DR Ensembl; ENSNBRT00000022309.1; ENSNBRP00000021725.1; ENSNBRG00000016632.1.
DR GeneTree; ENSGT00940000156778; -.
DR OMA; SMSDWLI; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000016632; Expressed in brain and 7 other cell types or tissues.
DR CDD; cd09492; SAM_SASH1_repeat2; 1.
DR CDD; cd11967; SH3_SASH1; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037630; SASH1_SAM_repeat2.
DR InterPro; IPR035720; SASH1_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR021090; SPIDER.
DR PANTHER; PTHR12301:SF3; SAM AND SH3 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR12301; SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF12485; SLY; 1.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 510..571
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 589..653
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1063..1127
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..887
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..930
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1132 AA; 124429 MW; 294515BDF64E11A6 CRC64;
MEGDQGTGAP SDEPQADSAA ASDSFSQLWS DVMGMLDGSL GNIDDLAQEY SEYYNTCFSD
VNDRMEELRK RRVSQELDMV NTRKWDSKKK NKSFWQNFRK SQHKPVVRQT SKGLCGSIIT
MSDEERIQLM MMVKEKMITV EEALARLKEY ERSRQSSSTD TAEWADGSAP NLNQSSNCNS
REQSDDEQSE DSVKFKRLHK LVNSTRRVRK KLIKVEEGKK HASEDFLNLE TPPTCEDNTA
LYTGVLKKPP LHQEASLPSL THDQLSLDGD TDGLTTSPSS SSLDTWSGHK LVKTFNKSSS
THGLIRPPRR TPAGSSALGG SIPGVTGSGS SFSELDGCGL DDDGKLSRST TDGEMRKALN
SISHGRTCSF GGFDLSNRSL HVVNAGNEQE AIYREVVKSP TTSRISLGKK VKSVKETMRK
RMSKKYSSSP SEQSSPDAAP GSPQSPLPDT DSLEKPKLKA GGSVESLRSS LSGQSSMSGQ
TVSTTDSSTS NRESVKSEDG DDEEPPYRGP FCGRARVHTD FTPSPYDTDS LKLKRGDVID
IISKPPMGTW MGLLNNKVGT FKFIYVDVLS EEEEKPKRPV RRRRKGRPPK PTSVEELLDR
IDLKDYMPTF LFNGYEDLDT FKLLEEEDLD ELNISDPQHR AVLLTAVELL QEYDSSSDPE
RSGMSGSQEK LLLEGRSIVG DSPRDSGCYE SNENLENGKS RKATSHFSAG HQSPDYPTLP
MTLSTEALQQ NSKNQRTKFP KSFFIKPSLK GFNLLGLRKA QRRSPIPASR SCEDLDGPPQ
PTGPWKRSHS LGDLQNFEQK NDLSVELKLS KEIPKSGKTS PIKPCRDAVS PAQNGTPTVS
PKGRADRPPV PSQLRLRSSC PTSMSSNPPE VMRTHPKKPP IPPPVPAKKS RERLANGLRH
PPLSLPSSPS PTASPGLSAP ALPPKTPSTP ASPCATSSAS SMGEESGTPP AVQPPWLLDL
GGKMAVTRKL SHTKIGPDLF TLLEQRLQSE GIDLTEEPYS DKHGRCGIPH PLVQRYSEDL
EQPVKDVAST IDQLRVKELR KQHRMAIPSG GLTEMCRKPP TLGNISTVSD WLISIGLPMY
STTLATAGID TLSRVALLTE SSAWEAGVRD ERHVRRLICE ARSVHAHREV QS
//
