ID A0A3Q4HEP2_NEOBR Unreviewed; 608 AA.
AC A0A3Q4HEP2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Neurexin-2-beta-like {ECO:0000313|Ensembl:ENSNBRP00000015282.1};
GN Name=NRXN2 {ECO:0000313|Ensembl:ENSNBRP00000015282.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000015282.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000015282.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR AlphaFoldDB; A0A3Q4HEP2; -.
DR Ensembl; ENSNBRT00000015699.1; ENSNBRP00000015282.1; ENSNBRG00000011787.1.
DR GeneTree; ENSGT00940000155978; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000011787; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR InterPro; IPR027789; Syndecan/Neurexin_dom.
DR PANTHER; PTHR15036:SF52; NEUREXIN-2; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF01034; Syndecan; 1.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..608
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018611889"
FT TRANSMEM 533..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 68..268
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 440..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..608
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 608 AA; 65818 MW; 560252CE7FB5E198 CRC64;
GGGDCPAFLF RLVLSLALLV FPCPAVAARV SSSLSTTHHV HHFHNKHGTV PIAINRMPFL
TRGGHAGTTY IFGRGGALIT YTWPPNDRPS TRADRLAVGF STQLKEAVLV RVESARGLGD
YLELHIERGK VGVIFNVGTD DITIEESAVM VSDGKYHVVR FTRSGGNATL QVDNQPVIER
FPSGNFDNER LAIARQRIPY RLGRVVDEWL LDKGRQLTIF NSQAFIKIGG GEKGRHFQGQ
ISGLYYNGLQ VLKLAAEGDP NVQTQGNLRL VGDVPSVLTT DTTSTTPLAD MSTTIMETTT
TMATTTTRKQ RSPTMRDSVT QNSDDLLVAS AECPSDDEDL EECEPGNGGE LVLPIITVDS
LDPPSIATHY PVIPPPPTTY RPFLTLLETT KESLPLPNGR PPCPLDQEDC EETIEVSAYG
SGEMTESDDE DYYKNSALVT DRTVLPPPPA VEGGSAGGGS SSSSNNIPAG KMNTRDQVLL
PPAQPSLDPG HRRVPGITYP PNFPHVPTPD PTSPERGLPG AVEVQQSSST TGMVVGIVAA
AALCILILLY AMYKYRNRDE GSYQVDQSRN YISNSATQSN GALVKEKQPS TAKTVTKNKK
NKDKEYYV
//
