ID A0A3Q4HET0_NEOBR Unreviewed; 1348 AA.
AC A0A3Q4HET0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Limbin-like {ECO:0000313|Ensembl:ENSNBRP00000021785.1};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSNBRP00000021785.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000021785.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000021785.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 32507.ENSNBRP00000021785; -.
DR Ensembl; ENSNBRT00000022369.1; ENSNBRP00000021785.1; ENSNBRG00000016670.1.
DR GeneTree; ENSGT00940000154127; -.
DR OMA; IFFAQIK; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000016670; Expressed in testis and 3 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 294..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1035..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 803..830
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1035..1050
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1348 AA; 151789 MW; 15A9FBCFC34D8826 CRC64;
MLRVHFTVER VAICIYFLNI EVSCFSPAFL YSRCGPDVTR RTGVLEDTTG NQSCYNGTAL
STSWLSFSFC SCFFQAVQAP CIHIYLTGTV EIGEAKAFFG RGPLASSAPA GPWGHSFYSS
FLYVSNGLHL RNSRSTLTRY NLGHSLPQVQ SVVPPAAFGV KFHKCAQVKL DTDPPQLTFF
LLVRNVGPVG GTNLSQVAIR DSISGLVPLK SEGRVVERGY QTFAIESLLA GSQMVLNYTA
HVRSQKSEVL DLPAFLTFSN ASQNDVSMFG PLRANLTLRM NSTDRIYPNH GVHFAGFVAG
LFVTMVLLLL GFLAINVIGL RTRLNLLQKR RNRSDSDPEF ADSNLSETVK DEATFEDKIV
DTMVLEDPQN MYRALENLEM SSLLHATNNL EAIRIQIYKD VMSSLLARLQ FQGQASAQAQ
ERLLSVLHGQ LLGMEGRLKE ERGARMVALA GQCNLETREE MEAEHCREAA EKAQAELLCQ
HADQQELLQC SVILEKLHKL SQSQLQRILL VRHEEASAKL QRQIIEWRRV ELHKIFSEEL
EEATRMGELE KSTAKNLQHK YFTCQDQLEE VLDVVLANLR YVLAERSAQR KFLVHSLHSL
NSLISDTFSS TSSNLDSWFT YIRGGSKLPA VQVDHLQEKA QKDLVMLRQR LDEALKQERR
AMHCGLIKKR RELISDMVTV HKQRQKDLSN MCKGLEGGIE VGQHLHCWQN LLTAHSLELA
ELINNLDEEA AADIRKVTMR VIQGAIADIK AIQPSAAQAV SALLPPGEQD FPLQMEPGQG
SGQGASALLV GQERLHQEGK AALRILSSTR EALKEDMEKE LQEQKALRTR CKDFFRCLCL
SQLTLSEDDR LKMKLEFQKC LSVIDRCLVM PHAVARTKLL CALAAWRKES EKQMMNTQSK
GKTSEARQKA DTSDLQLFQK KLKDRIQLYE REKEMESSIM SKVLEEMTHE REDDLHSQAD
SLAVQMAIIH YQKAERRTKV LETCRAMLTL HSLLVQQLKE RKHLERQDMA QSIQSHSYKF
SFSEQQLQEE RTNLDSLQMS QPTIKSSKTH QEDSGVGDEN CEQETVFQLQ TDCRMGAILQ
DALYKREQVT SLMAERFHLM TAKSQSMEDL KEQMELKRLY ANCDQDLDFA SQLVKRCHVS
TEVLLEALRL LLPTLPESEL LSISDALCPK QHPPSGSAEQ EHPGCAEELN RVLPVKLRED
VVHKNMLNIP SCAVDKEGLQ EKRQSLMEKL LPRSGLVLQG DTAPLLTKEK GKNICSKAQQ
PVYKSGLPVK EQQSDSGREE FVDTVKEAEE HTTSASACCA PGSPATGEKL FVFRDPPESC
NSVDVPNRKR KRNFLNLKKG SVAPTNLP
//