ID A0A3Q4HF62_NEOBR Unreviewed; 1015 AA.
AC A0A3Q4HF62;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Formin-like protein 2-like {ECO:0000313|Ensembl:ENSNBRP00000020591.1};
GN Name=FMNL2 {ECO:0000313|Ensembl:ENSNBRP00000020591.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000020591.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000020591.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family.
CC {ECO:0000256|ARBA:ARBA00023449}.
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DR AlphaFoldDB; A0A3Q4HF62; -.
DR STRING; 32507.ENSNBRP00000020591; -.
DR Ensembl; ENSNBRT00000021148.1; ENSNBRP00000020591.1; ENSNBRG00000015789.1.
DR GeneTree; ENSGT00940000155515; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000015789; Expressed in camera-type eye and 6 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0060857; P:establishment of glial blood-brain barrier; IEA:Ensembl.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR043592; FMNL_animal.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR45857:SF5; FORMIN-LIKE PROTEIN 2; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 2.
DR Pfam; PF02181; FH2; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 22..469
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 620..1011
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 488..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 381..478
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 900..954
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 525..544
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..594
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1015 AA; 114861 MW; 99A856787985A46E CRC64;
MGNAGSMDHH TDLRGHNMPL KLPMPDAGEL EERFAIVLNS MNLPPDKARL LRQYDNEKKW
ELICDQERFQ VKNPPHTYLQ KLRSYLDPAV TRKKFRRRVQ ESTQVLRELE ISLRTNHIGW
VREFLNEENK GLDVLVDYLS FAQYAVTFDG ECLENNPEAA MDKSKPWSRS IEDLHGGSTL
PSPITGNGIT RVGRHSTLRF NTLPSRRTLK NSRLVCKKDD VHVCIMCLRA IMNYQYGFNM
VMSHPHAVNE IALSLNNKNP RTKALVLELL AAVCLVRGGH EIILSAFDNF KEVCMEEQRF
EKLMEYFKNE DNNIDFMVAC MQFINIVVHS VEDMNFRVHL QYDFTKLCLD DYLDKLKHTE
SDKLQVQIQA YLDNVFDVGA LLEDAETKNA ALERVEELEE NISHMTEKLQ DMENEAMAKI
VELEKQLMQR NKELESIREV YKDASSQVHS LRQMLKEKDE AIQRQSKLEK KIHELEKQGT
IKIHKKGDGD ISILTSPPSA TEGSPGAVIG GNGVAVSPNH VALMAGTPVP PPPPPPPPPL
PMNGTLSNGP TSTIPAAAPP PPPPPPPPPP PPPGMPTETS APLPPPPPPV APPLPGCGTP
TVIMNSGLAE GPIKLFSVKI KKPIKTKFRM PVFNWVALKP NQINGTVFNE IDDERILEDL
NVDEFEEMFK TKAQGPPIDL TASKQKVIQK GPNKVALLDS NRAKNLAITL RKVGKTPEEI
CKAIQLFDLR TLPVDFVECL MRFQPTENEI KVLRQFEKER KPLESLTDED RFMMQFSKIE
RLMQKMTIMA FIGNFAESVQ MLTPQLHAVI AASVSIKSSQ KLKKILEIIL ALGNYMNSSK
RGAVYGFKLQ SLDLLLDTKS TDRKQTLLHY IANVVKEKYT QVSLFYNEMH YVEKAAAVSL
ENVLLDVKEL QRGMELTKRE YSMHGHNTML KEFIAHNESK LKKLQDDAKI AQDAFDEVVK
FFGENAKTTP PSVFFPVFVR FVKAYRVSWI LASHIGQKQT KHTLLSMINS SLHFI
//
