ID A0A3Q4HHD8_NEOBR Unreviewed; 2500 AA.
AC A0A3Q4HHD8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Filamin-B-like {ECO:0000313|Ensembl:ENSNBRP00000019853.1};
GN Name=FLNB {ECO:0000313|Ensembl:ENSNBRP00000019853.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000019853.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000019853.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR STRING; 32507.ENSNBRP00000019853; -.
DR Ensembl; ENSNBRT00000020376.1; ENSNBRP00000019853.1; ENSNBRG00000015211.1.
DR GeneTree; ENSGT00940000156286; -.
DR OMA; RAVPCKV; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000015211; Expressed in zone of skin and 4 other cell types or tissues.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 23.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537:SF7; FILAMIN-B; 1.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 23.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 23.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 23.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 23.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 16..122
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 136..239
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 246..341
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 343..441
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 442..538
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 539..631
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 635..731
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 732..834
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 835..926
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 927..1023
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1024..1116
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1117..1213
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1214..1313
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1314..1406
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1407..1502
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1503..1598
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1595..1688
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1685..1770
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1811..1891
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1894..1986
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1984..2082
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2085..2177
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2179..2272
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2276..2368
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2405..2499
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 242..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2500 AA; 265846 MW; 3F73D1FAF6A058E5 CRC64;
MPATEKDLAE DAPWKKIQQN TFTRWINEHL KCVNKRIVDL QLDLGDGLRL IALLEVLSHK
KMYRKYHPRP TFRQMKLENV SVALEFLEKE NIKLVSIDSK AIVDGNLKLI LGLVWTLILH
YSISMPVWEG EDAESKTPKQ RLLGWIQHKV PDLPITNFSQ DWRDGKVLGA LVDSCAPGLC
PDWETWDPVR PVENATEAMQ LADDWLGIPQ VIAPEEIIDP SADEQSVMTY LSQFPKAKLK
PGAPLKPKLN PKKARAYGPG IEPTGNRVLR PAVFTVDTFS AGQGQVTVYL DHPDGTREEV
KSTSGKKTYS VTYIPQVMGA HQVTVLFAGQ EIPKSPFEVN VDKALGDASK VTVKGPGVEP
VGNIANKPTY FDIYTAGAGT GDVTAMIKDP QGRQNTVEVM MEDKGDSVYR CTYRPTQGGP
HTITVTFGGV GIPKSPFSVD VGPACMPGAC RATGRGLQPS GLRVKQVGDI KVDTRNAGSG
ELKVTVKGPK GVEEPVKQLS SQDGVFSFEY HPSSPGKYIV SITWGGQHIP KSPFEVTVGQ
QAGPQQIRAW GPGLEGGIVG KPATFVVESI GTDVGVLGFA IEGPSQAKIE CEDQNDGSCD
VRYWPTEPGE YAVHVTCDEE DIEHSPFMAF IIPDNNTSFP DKVQAYGPGL EKSGCVVNQP
AEFTVNAEHA GKGPLNITAQ DAEGLPVEVK MRSKGDGLYS CSYTPTSSLK HTVAVSWAGV
GIPKSPFRVN VGKGSHPNMV KVFGPGVERS GLKANEPTHF TVDCSGAGDG DVGVGIKCDA
NMISDKEADV DFDIIPNAND TFTVKYIPPA AGRLTIKVLF TDKEVPQSPF SVKVDPSHDA
SKVKAEGPGL ARVESGKPTH FTVLTKGAGK APLDVTFSSA VKDFDIIDNY DYSQTVKYTP
AQQGELTILV KFGGDPIAKS PFTVGVAAPL DLSKVTVDNM DGRVEVNQEQ QFMVDTKGAG
GQGHLVVELL SPSQQAVPCK VEPQPGKADV SLVCYTPTKE GVYAVNVSYD GHPIPGSPFP
VEAHLPPDPS KVKAFGPGLK GGLVGNPAEF TIDTKGAGTG GLGLTVEGPT EAKIECSDNG
DGTCSVSYLP TEPGDYLVNI LFENVHIPGS PFRADIQMPF DPSKVVASGS GLKRAKVGET
SVVNVDCSQA GPGELSLEAA LDSPPSAKAK TEIVDNKDGT YTVTYIPLTS GMYTLLLKYG
GKTVPGFPAK VMADPAVDTS KVKVFGPGVE GQAVFREATT EFTVDARSLT RRGGDHIKAV
VKNPSGALTD CGVTDKADGT YCVEYTPFEN GVHSVQVLYD DTPVPNSPFR VSVSEGCDPS
RVVATGPGLE QGLTDQPNNF NIFTRGAGIG GLGITVEGPS ESKMSCTDNK DGSCSVEYIP
FTPGNYDVNI TYGGEHIPGS PFKVPVKDVV DSSKVKVSGP GVASGVRANI PQSFTVDCRK
AGVAPLAVAV TAPKGIAEPV EVTDNGDGTH TVSYTPSVEG PYSVAVKYAE EDVPHSPFKF
RVLPTHDASK VRASGPGLTS GVPASFPVEF NIDAKDAGQG QLSVLITDQD GKPKQPRIHD
NGDGTYRVSY VPDRAGRYTI VIKYGGDDIP ASPYRVRATA TGDASKCVGP TVAIGEELGL
VVNAKGAGKG KVSCVVVQPD GTEVEAEVLE NEDGTFDIFY TAPAPGNYVI YVRFGGENIP
RSPFKVTVTS ESYQPDGTSV NGSGFRPFDM VIPFAFRKGE ITGEVLMPSG KSAQPLITDN
LDGTVTVQYS PTEAGLHEMH IKYNGTHIPG KRIHSCDIST MIRTLIVAPM HNISTVNCLA
VDYFATDDNQ RRSQVKLGSA ADFSLDINET DLSLLSASIR SPSGRDEPCL LKRMANNHIG
ISFIPREVGE HQVSILKNGR HVANSPITIM VVQSEIGDAS RVKAHGDGLV QGTTFSNSSF
IVDTREAGYG GLALSIEGPS KVDIQTEDME DGTCRVTYCP TEPGNYIVSI RFAEEHVPGS
PFTVRVTGEG RIRESITRRQ KAASVATVGS VCDLSLKIPA IDMQDVTAEV TSPSGASQPA
ELVATGNDAY CVRFVPTEMG VHSVSVKYRG VHVPGSPFQF TVGPLGEGGA GKVRAGGPGL
EGALAGEPAE FTIWTREAGA GGLSVAVEGP SRAEISFDDR KDGSCGISYV AQEPGDYEVS
VKFNDQHIPD SPYLVPVVAP VNDARRLSVA GLQESGLKVN HPASFAVRLN GAKGKMDAKV
HSPSGALEKC VVTELERDKY AIRFIPRENG VHTIDVKFNG CHIPGSPFQV RVGEPGQTGE
PGLVSAYGSG LERGTTGTQS EFIINNTKAG PGSLAVTIEG PSKVKMDCQE VPEGYKVQYT
PMAPGNYLIS IKYGGPNHIT GSPFKAKVTG PRLVNVTNAS ETSTLTLDPA IRASSSFTQS
AMPRLGDSDA SKVVSRGAGL SKAFVGQRSN FTVDCSKAGK NMLLVGVHGP QVPCDEVLVK
HMGNLQYNVS YVLKERGNYI LVVKWGEDHI PGSPFHVAVP
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